Publication result detail
Fate of Enrofloxacin and Its Metabolites in Chicken Faeces after Antibiotic Treatment
HAMPLOVÁ, M.; PARTOVI NASR, M.; ČEJKOVÁ, D.; FARKOVÁ, V.; ZLÁMALOVÁ GARGOŠOVÁ, H.
Original Title
Fate of Enrofloxacin and Its Metabolites in Chicken Faeces after Antibiotic Treatment
English Title
Fate of Enrofloxacin and Its Metabolites in Chicken Faeces after Antibiotic Treatment
Type
Conference proceedings
Original Abstract
This study investigates the occurrence, persistence, and degradation behaviour of the antibiotic enrofloxacin (ENR) and its microbiologically active metabolites in fecal samples from chickens reared at a commercial farm in the Czech Republic. An optimised ultrasound-assisted extraction method followed by UHPLC-ESI-TQ was used for the quantification of ENR and its metabolites. ENR was detected in all samples at concentrations reaching tens of mg/kg, while ciprofloxacin (CIP) and another identified metabolite and degradation product were also consistently present. Both ENR and CIP concentrations decreased exponentially over time, following first-order elimination and degradation kinetics. Despite this decline, ENR residues persisted even one month after the treatment. The results demonstrate that poultry manure contains significant levels of active antibiotic residues and metabolites, highlighting the environmental risk associated with of applying improperly treated chicken excrement to fields as fertiliser and its potential contribution to the spread of antibiotic resistance.
English abstract
This study investigates the occurrence, persistence, and degradation behaviour of the antibiotic enrofloxacin (ENR) and its microbiologically active metabolites in fecal samples from chickens reared at a commercial farm in the Czech Republic. An optimised ultrasound-assisted extraction method followed by UHPLC-ESI-TQ was used for the quantification of ENR and its metabolites. ENR was detected in all samples at concentrations reaching tens of mg/kg, while ciprofloxacin (CIP) and another identified metabolite and degradation product were also consistently present. Both ENR and CIP concentrations decreased exponentially over time, following first-order elimination and degradation kinetics. Despite this decline, ENR residues persisted even one month after the treatment. The results demonstrate that poultry manure contains significant levels of active antibiotic residues and metabolites, highlighting the environmental risk associated with of applying improperly treated chicken excrement to fields as fertiliser and its potential contribution to the spread of antibiotic resistance.
Keywords
enrofloxacin; ciprofloxacin; metabolites; poultry; UHPLC-ESI-TQ; mass spectrometry, antibiotic residues; degradation kinetics; livestock farming; antibiotic resistance
Key words in English
enrofloxacin; ciprofloxacin; metabolites; poultry; UHPLC-ESI-TQ; mass spectrometry, antibiotic residues; degradation kinetics; livestock farming; antibiotic resistance
Authors
HAMPLOVÁ, M.; PARTOVI NASR, M.; ČEJKOVÁ, D.; FARKOVÁ, V.; ZLÁMALOVÁ GARGOŠOVÁ, H.
Released
26.11.2025
Publisher
Fakulta chemickej a potravinárskej technológie
Location
Bratislava
ISBN
978-80-8208-162-9
Pages count
2
URL
BibTex
@proceedings{BUT199639,
editor="Marie {Hamplová} and Minoo {Partovi Nasr} and Darina {Čejková} and Veronika {Farková} and Helena {Zlámalová Gargošová}",
title="Fate of Enrofloxacin and Its Metabolites in Chicken Faeces
after Antibiotic Treatment",
year="2025",
pages="2",
publisher="Fakulta chemickej a potravinárskej technológie",
address="Bratislava",
isbn="978-80-8208-162-9",
url="https://doi.org/10.5281/zenodo.17647142"
}Documents