Publication detail

Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots

Küçüktürkmen, B. Öz, UC. Er, E. Gómez, IJ. Tekneci, SI. Esim,Ö. Ozköse, UU. Gülyüz, S. Üstündag, A. Yilmaz,Ö. Zajícková, L. Bozkir, A.

Original Title

Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots

Type

journal article in Web of Science

Language

English

Original Abstract

In recent years, multifunctional nanocarriers that provide simultaneous drug delivery and imaging have attracted enormous attention, especially in cancer treatment. In this research, a biocompatible fluorescent multifunctional nanocarrier is designed for the co-delivery of capsaicin (CPS) and nitrogen-doped graphene quantum dots (N-GQDs) using the pH sensitive amphiphilic block copolymer (poly(2-ethyl-2-oxazoline)-b-poly(epsilon-caprolactone), PEtOx-b-PCL). The effects of the critical formulation parameters (the amount of copolymer, the concentration of poly(vinyl alcohol) (PVA) as a stabilizing agent in the inner aqueous phase, and volume of the inner phase) are evaluated to achieve optimal nanoparticle (NP) properties using Central Composite Design. The optimized NPs demonstrated a desirable size distribution (167.8 +/- 1.4 nm) with a negative surface charge (-19.9 +/- 0.4) and a suitable loading capacity for CPS (70.80 +/- 0.05%). The CPS & N-GQD NPs are found to have remarkable toxicity on human breast adenocarcinoma cell line (MCF-7). The solid fluorescent signal is acquired from cells containing multifunctional NPs, according to the confocal microscope imaging results, confirming the significant cellular uptake. This research illustrates the enormous potential for cellular imaging and enhanced cancer therapy offered by multifunctional nanocarriers that combine drug substances with the novel fluorescent agents. In this research, a biocompatible fluorescent multifunctional nanocarrier for co-delivery of capsaicin (CPS) and nitrogen-doped graphene quantum dots (N-GQDs) using the pH-sensitive amphiphilic block copolymer (poly(2-ethyl-2-oxazoline)-b-poly(epsilon-caprolactone), PEtOx-b-PCL) is designed. This research illustrates the enormous potential for cellular imaging and enhanced cancer therapy offered by multifunctional nanocarriers. image

Keywords

amphiphilic block copolymers; Capsaicin; nanoparticle; N-GQDs; theranostic

Authors

Küçüktürkmen, B.; Öz, UC.; Er, E.; Gómez, IJ.; Tekneci, SI.; Esim,Ö.; Ozköse, UU.; Gülyüz, S.; Üstündag, A.; Yilmaz,Ö.; Zajícková, L.; Bozkir, A.

Released

1. 9. 2024

Publisher

WILEY-V C H VERLAG GMBH

Location

WEINHEIM

ISBN

1616-5195

Periodical

MACROMOLECULAR BIOSCIENCE

Year of study

24

Number

9

State

Federal Republic of Germany

Pages count

13

URL

https://onlinelibrary.wiley.com/doi/10.1002/mabi.202400149

BibTex

@article{BUT190003,
  author="Küçüktürkmen, B. and Öz, UC. and Er, E. and Gómez, IJ. and Tekneci, SI. and Esim,Ö. and Ozköse, UU. and Gülyüz, S. and Üstündag, A. and Yilmaz,Ö. and Zajícková, L. and Bozkir, A.",
  title="Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots",
  journal="MACROMOLECULAR BIOSCIENCE",
  year="2024",
  volume="24",
  number="9",
  pages="13",
  doi="10.1002/mabi.202400149",
  issn="1616-5195",
  url="https://onlinelibrary.wiley.com/doi/10.1002/mabi.202400149"
}