Publication detail

Hippocampal subfield volumetric changes after radiotherapy for brain metastases

HOLÍKOVÁ, K. SELINGEROVÁ, I. POSPÍŠIL, P. BULÍK, M. HYNKOVÁ, L. KALOUSKOVÁ, I. HNIDÁKOVÁ, L. BURKOŇ, P. SLÁVIK, M. ŠÁNA, J. HOLEČEK, T. VANÍČEK, J. ŠLAMPA, P. JANČÁLEK, R. KAZDA, T.

Original Title

Hippocampal subfield volumetric changes after radiotherapy for brain metastases

Type

journal article in Web of Science

Language

English

Original Abstract

Background Changes in the hippocampus after brain metastases radiotherapy can significantly impact neurocognitive functions. Numerous studies document hippocampal atrophy correlating with the radiation dose. This study aims to elucidate volumetric changes in patients undergoing whole-brain radiotherapy (WBRT) or targeted stereotactic radiotherapy (SRT) and to explore volumetric changes in the individual subregions of the hippocampus.Method Ten patients indicated to WBRT and 18 to SRT underwent brain magnetic resonance before radiotherapy and after 4 months. A structural T1-weighted sequence was used for volumetric analysis, and the software FreeSurfer was employed as the tool for the volumetry evaluation of 19 individual hippocampal subregions.Results The volume of the whole hippocampus, segmented by the software, was larger than the volume outlined by the radiation oncologist. No significant differences in volume changes were observed in the right hippocampus. In the left hippocampus, the only subregion with a smaller volume after WBRT was the granular cells and molecular layers of the dentate gyrus (GC-ML-DG) region (median change -5 mm3, median volume 137 vs. 135 mm3; P = .027), the region of the presumed location of neuronal progenitors.Conclusions Our study enriches the theory that the loss of neural stem cells is involved in cognitive decline after radiotherapy, contributes to the understanding of cognitive impairment, and advocates for the need for SRT whenever possible to preserve cognitive functions in patients undergoing brain radiotherapy.

Keywords

brain; hippocampus; metastasis; radiotherapy; volumetry

Authors

HOLÍKOVÁ, K.; SELINGEROVÁ, I.; POSPÍŠIL, P.; BULÍK, M.; HYNKOVÁ, L.; KALOUSKOVÁ, I.; HNIDÁKOVÁ, L.; BURKOŇ, P.; SLÁVIK, M.; ŠÁNA, J.; HOLEČEK, T.; VANÍČEK, J.; ŠLAMPA, P.; JANČÁLEK, R.; KAZDA, T.

Released

1. 1. 2024

Publisher

OXFORD UNIV PRESS

Location

OXFORD

ISBN

2632-2498

Periodical

Neuro-Oncology Advances

Year of study

6

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

9

Pages count

9

URL

https://academic.oup.com/noa/article/6/1/vdae040/7632607

BibTex

@article{BUT197322,
  author="Klára {Holíková} and Iveta {Selingerová} and Petr {Pospíšil} and Martin {Bulík} and Ludmila {Hynková} and Ivana {Kalousková} and Lucie {Hnidáková} and Petr {Burkoň} and Marek {Slávik} and Jiří {Šána} and Tomáš {Holeček} and Jiří {Vaníček} and Pavel {Šlampa} and Radim {Jančálek} and Tomáš {Kazda}",
  title="Hippocampal subfield volumetric changes after radiotherapy for brain metastases",
  journal="Neuro-Oncology Advances",
  year="2024",
  volume="6",
  number="1",
  pages="1--9",
  doi="10.1093/noajnl/vdae040",
  issn="2632-2498",
  url="https://academic.oup.com/noa/article/6/1/vdae040/7632607"
}