Publication detail

Polyhydroxyalkanoates as Functional Biomaterials for 3D-Printable Hydrogels

ČERNEKOVÁ, N. KADLECOVÁ, Z. SEDLÁČEK, P. SMILEK, J. VOJTOVÁ, L. KOVALČÍK, A.

Original Title

Polyhydroxyalkanoates as Functional Biomaterials for 3D-Printable Hydrogels

Type

abstract

Language

English

Original Abstract

represent a fascinating and crucial class of materials, consisting of a hydrophilic cross-linked polymer network that retains a significant amount of water within its structure. Their unique properties have driven extensive research leading to the development of innovative hydrogel materials for biomedicine, such as scaffolds or implants. In this regard, additive manufacturing, including 3D printing, has become a powerful technology for fabricating patient-specificimplants with the potential to heal critical-sized defects (1). Polyhydroxyalkanoates (PHAs) have attractedsignificant interest in the biomedical industry as well (2). As intracellular bio-polyesters produced by microorganisms, they stand out for their biodegradability, biocompatibility and wide range of mechanical properties. Since the final mechanical properties of hydrogels depend on their (bio)polymeric material, PHAs seem to be a very suitable source for their use in biomedicine. But is it even possible to prepare a hydrogel, a hydrophilic material from hydrophobic PHAs without the need for their chemical modification? Their hydrophobic nature is incompatible with hydrogel principles. Herein, we overcame this limitation using a solvent-exchange method (3). This method involves dissolving the polymer in a suitable water miscible solvent andexchanging the solvent with water to form hydrogels. We designed hydrogels based on different types of PHAs. The effect of varying the composition, additives, solvent or solvent-exchange method on mechanical properties of hydrogels has been compared. The use of PHAs in 3D printingof hydrogels has been described as well

Keywords

polyhydroxyalkanoates; 3D-printing, hydrogels

Authors

ČERNEKOVÁ, N.; KADLECOVÁ, Z.; SEDLÁČEK, P.; SMILEK, J.; VOJTOVÁ, L.; KOVALČÍK, A.

Released

28. 4. 2025

Publisher

Czech Chemical Society

Location

Praha, Czech Republic

ISBN

2336-7210

Book

XIVth INTERDISCIPLINARY MEETING OF YOUNG LIFE SCIENTISTS

Edition number

1.

ISBN

2336-7210

Periodical

Czech Chemical Society Symposium Series

Year of study

23

Number

2

State

Czech Republic

Pages from

27

Pages to

27

Pages count

72

URL

http://www.ccsss.cz/index.php/ccsss/issue/view/50/90

BibTex

@misc{BUT198389,
  author="Nicole {Černeková} and Zuzana {Kadlecová} and Petr {Sedláček} and Jiří {Smilek} and Lucy {Vojtová} and Adriána {Kovalčík}",
  title="Polyhydroxyalkanoates as Functional Biomaterials for 3D-Printable Hydrogels",
  booktitle="XIVth INTERDISCIPLINARY MEETING OF YOUNG LIFE SCIENTISTS",
  year="2025",
  edition="1.",
  journal="Czech Chemical Society Symposium Series",
  volume="23",
  number="2",
  pages="27--27",
  publisher="Czech Chemical Society",
  address="Praha, Czech Republic",
  isbn="2336-7210",
  issn="2336-7210",
  url="http://www.ccsss.cz/index.php/ccsss/issue/view/50/90",
  note="abstract"
}