Patent detail
Synthesis of paliperidone
Jiri Bartl, Petr Benovsky, Jozef Krajcovic
Patent type
Patent
Abstract
A 9-hydroxy or 9-acyloxy group can be added to a pyridopyrimidinone ring structure by a process comprising acylating a compound of formula (5) under Vilsmeier-Haack or Friedel-Crafts conditions to form a compound (6); and transforming with a peroxo-compound to obtain the compound (I). R represents hydrogen or a C1-C20 acyl group. The process is useful in the synthesis of paliperidone and derivatives.
Patent number
WO2009074333A1
Date of application
10. 12. 2008
Date of registration
18. 6. 2009
Publisher
Úřad průmyslového vlastnictví (patentový úřad České republiky)
Owner
SYNTHON B.V. Microweg 22, NL-6545 CM Nijmegen
Possibilities of use
In order to use the result by another entity, it is always necessary to acquire a license
Licence fee
The licensor does not require a license fee for the result