Publication result detail
Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one
EL-SHAMY, I.; BAKEER, H.; AL-SHAMRANI, K.; ABDEL-LATTIF, A.; AL-SHEHRI, M.
Original Title
Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one
English Title
Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one
Type
Scopus Article
Original Abstract
A series of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (3) and 2-((1-substituted- 1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (4) were synthesized starting from 4-arylphthalazin- 1(2H)-one (1). Moreover, the N-glycosyl of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (5a,b) were synthesized by interaction of phthalazinone derivative (3) with acetobromo-alfa-D-glucose. Deacetylation of acetylated N-nucleosides 5a,b using ammonia solution in methanol afforded the corresponding deacetylatedNglycosyl 6a,b respectively. The structures of the synthesized compounds were confirmed by 1HNMR, 13CNMR, MS, IR spectroscopy and by elemental analysis.
English abstract
A series of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (3) and 2-((1-substituted- 1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (4) were synthesized starting from 4-arylphthalazin- 1(2H)-one (1). Moreover, the N-glycosyl of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (5a,b) were synthesized by interaction of phthalazinone derivative (3) with acetobromo-alfa-D-glucose. Deacetylation of acetylated N-nucleosides 5a,b using ammonia solution in methanol afforded the corresponding deacetylatedNglycosyl 6a,b respectively. The structures of the synthesized compounds were confirmed by 1HNMR, 13CNMR, MS, IR spectroscopy and by elemental analysis.
Keywords
N-glycosyl; phthalazinone; antimicrobial activity, Benzamidazole
Key words in English
N-glycosyl; phthalazinone; antimicrobial activity, Benzamidazole
Authors
EL-SHAMY, I.; BAKEER, H.; AL-SHAMRANI, K.; ABDEL-LATTIF, A.; AL-SHEHRI, M.
RIV year
2015
Released
01.04.2014
ISBN
1097-8135
Periodical
Life Science Journal
Volume
11
Number
4
State
People's Republic of China
Pages from
94
Pages to
99
Pages count
6
BibTex
@article{BUT112296,
author="Ibrahim E. {El-Shamy} and Hadeer M. {Bakeer} and Khalid M. {Al-Shamrani} and Abdelmohsen Moustafa {Abdellatif} and Mohammed M. {Al-Shehri}",
title="Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one",
journal="Life Science Journal",
year="2014",
volume="11",
number="4",
pages="94--99",
issn="1097-8135"
}