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Wound Dressing Material Fabricated from Silver/Hyaluronan Bio-nanocomposite Fiber
ABDEL-LATTIF, A.; JANČÁŘ, J.
Original Title
Wound Dressing Material Fabricated from Silver/Hyaluronan Bio-nanocomposite Fiber
English Title
Wound Dressing Material Fabricated from Silver/Hyaluronan Bio-nanocomposite Fiber
Type
Audiovisual work
Original Abstract
In-situ formed hyaluronan/silver (HA/Ag) nanoparticles (NPs) were used to prepare composite fibers for the first time. Sodium hyaluronate was dissolved in demineralized water to obtain good solution. Silver nitrate was added at ambient temperature, then the pH slightly was increased to 8 by adding few drops of sodium hydroxide. The in-situ formed HA/Ag-NPs were used to prepare fibers by wet-dry-spinning technique (WDST). The antibacterial performance of medical HA/AgNP fibers were evaluated against gram negative bacterial (E. coli), exhibiting excellent bactericidal activity. The fibers did not show any cytotoxicity against human keratinocyte cell line (HaCaT). In-vivo animal tests indicated that the prepared fiber dressing has excellent healing efficacy compared to the neat HA and greatly accelerated the healing process. Based on our results, the new HA/Ag nonwoven wound dressing can be used in treating wounds and chronic ulcers as well as cell carrier in different biological research and tissue engineering
English abstract
In-situ formed hyaluronan/silver (HA/Ag) nanoparticles (NPs) were used to prepare composite fibers for the first time. Sodium hyaluronate was dissolved in demineralized water to obtain good solution. Silver nitrate was added at ambient temperature, then the pH slightly was increased to 8 by adding few drops of sodium hydroxide. The in-situ formed HA/Ag-NPs were used to prepare fibers by wet-dry-spinning technique (WDST). The antibacterial performance of medical HA/AgNP fibers were evaluated against gram negative bacterial (E. coli), exhibiting excellent bactericidal activity. The fibers did not show any cytotoxicity against human keratinocyte cell line (HaCaT). In-vivo animal tests indicated that the prepared fiber dressing has excellent healing efficacy compared to the neat HA and greatly accelerated the healing process. Based on our results, the new HA/Ag nonwoven wound dressing can be used in treating wounds and chronic ulcers as well as cell carrier in different biological research and tissue engineering
Keywords
Hyaluronan, in-situ silver, cytotoxicity, wound dressing
Key words in English
Hyaluronan, in-situ silver, cytotoxicity, wound dressing
Authors
ABDEL-LATTIF, A.; JANČÁŘ, J.
RIV year
2017
Released
17.10.2015
Publisher
Agnieszka Zarzycka
Location
POLAND
Pages from
12
Pages to
12
Pages count
1
Full text in the Digital Library
BibTex
@misc{BUT118700,
author="Abdelmohsen Moustafa {Abdellatif} and Josef {Jančář}",
title="Wound Dressing Material Fabricated from Silver/Hyaluronan Bio-nanocomposite Fiber",
year="2015",
pages="12--12",
publisher="Agnieszka Zarzycka",
address="POLAND",
note="Audiovisual work"
}