Result with impact on practice detail
Novel Chitin/chitosan-glucan Wound Dressing: Isolation, Characterization and Medical Applications
ABDEL-LATTIF, A.; HRDINA, R.; HEBIESH, A.; JANČÁŘ, J.
Original Title
Novel Chitin/chitosan-glucan Wound Dressing: Isolation, Characterization and Medical Applications
English Title
Novel Chitin/chitosan-glucan Wound Dressing: Isolation, Characterization and Medical Applications
Type
Audiovisual work
Original Abstract
Chitin/chitosan-glucan complex (ChCsGC) was isolated from schizophyllum commune (S. commune) and dissolved for the first time in precooled (-15 °C) 8 wt. % urea/6 wt. % NaOH aqueous solution. Novel nonwoven microfiber mats were fabricated by wet-dry-spinning technique and evaluated the mechanical and surface morphology. Prepared materials were characterized employing FTIR-ATR, Optical microscope, TGA, DSC, H/C-NMR, SEM and XRD techniques. The biological activity of the nonwoven ChCsGC fabric was tested against Escherichia coli (E.coli) bacteria exhibiting excellent antibacterial activity. The cell viability of the extracted complex and nonwovens were evaluated utilizing mouse fibroblast cell line varying concentration and treatment time. ChCsGC didn’t show any cytotoxicity against mouse fibroblast cells. The novel ChCsGC nonwovens exhibited excellent surgical wound healing ability of when tested using rat models.
English abstract
Chitin/chitosan-glucan complex (ChCsGC) was isolated from schizophyllum commune (S. commune) and dissolved for the first time in precooled (-15 °C) 8 wt. % urea/6 wt. % NaOH aqueous solution. Novel nonwoven microfiber mats were fabricated by wet-dry-spinning technique and evaluated the mechanical and surface morphology. Prepared materials were characterized employing FTIR-ATR, Optical microscope, TGA, DSC, H/C-NMR, SEM and XRD techniques. The biological activity of the nonwoven ChCsGC fabric was tested against Escherichia coli (E.coli) bacteria exhibiting excellent antibacterial activity. The cell viability of the extracted complex and nonwovens were evaluated utilizing mouse fibroblast cell line varying concentration and treatment time. ChCsGC didn’t show any cytotoxicity against mouse fibroblast cells. The novel ChCsGC nonwovens exhibited excellent surgical wound healing ability of when tested using rat models.
Keywords
Chitin/chitosan-glucan complex, nonwoven mat, surgical wound healing
Key words in English
Chitin/chitosan-glucan complex, nonwoven mat, surgical wound healing
Authors
ABDEL-LATTIF, A.; HRDINA, R.; HEBIESH, A.; JANČÁŘ, J.
RIV year
2017
Released
14.06.2016
ISBN
978-80-86238-82-1
Full text in the Digital Library
BibTex
@misc{BUT126928,
author="Abdelmohsen Moustafa {Abdellatif} and Radim {Hrdina} and ali {hebiesh} and Josef {Jančář}",
title="Novel Chitin/chitosan-glucan Wound Dressing: Isolation, Characterization and Medical Applications",
year="2016",
isbn="978-80-86238-82-1",
note="Audiovisual work"
}