Publication result detail
Improving stability of co-amorphous drug system with addition of PVP
TÜRKEOVÁ, I.; ENEV, V.; KLUČÁKOVÁ, M.
Original Title
Improving stability of co-amorphous drug system with addition of PVP
English Title
Improving stability of co-amorphous drug system with addition of PVP
Type
Paper in proceedings (conference paper)
Original Abstract
Approximately 90% of small molecular weight drug candidates under development have poor aqueous solubility.One of the most promising approaches in the development of drug delivery systems to improve the efficacy of new drugs is the conversion of a crystalline drug to its respective amorphous counterpart. In this case we tried used aminoacid as stabilizer and PVP6, 7. As drug we used Indomethacin - poorly water soluble BCS class II drug. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation. We tried to prepare co-amorphous mixtures with aminoacid and polymer and will see that is working, is stable or not.
English abstract
Approximately 90% of small molecular weight drug candidates under development have poor aqueous solubility.One of the most promising approaches in the development of drug delivery systems to improve the efficacy of new drugs is the conversion of a crystalline drug to its respective amorphous counterpart. In this case we tried used aminoacid as stabilizer and PVP6, 7. As drug we used Indomethacin - poorly water soluble BCS class II drug. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation. We tried to prepare co-amorphous mixtures with aminoacid and polymer and will see that is working, is stable or not.
Keywords
co-amorphous system, PVP, indomethacin, amorf form
Key words in English
co-amorphous system, PVP, indomethacin, amorf form
Authors
TÜRKEOVÁ, I.; ENEV, V.; KLUČÁKOVÁ, M.
RIV year
2017
Released
03.12.2015
Publisher
Vysoké učení technické v Brně, Fakulta chemická
Location
Brno
ISBN
978-80-214-5290-9
Book
Sborník abstraktů 3. prosince 2015 - Studentská konference Chemie je život
Edition
1
Pages from
310
Pages to
316
Pages count
7
BibTex
@inproceedings{BUT129222,
author="Irena {Solná} and Vojtěch {Enev} and Martina {Klučáková}",
title="Improving stability of co-amorphous drug
system with addition of PVP",
booktitle="Sborník abstraktů 3. prosince 2015 - Studentská konference Chemie je život",
year="2015",
series="1",
number="1",
pages="310--316",
publisher="Vysoké učení technické v Brně, Fakulta chemická",
address="Brno",
isbn="978-80-214-5290-9"
}