Publication result detail

Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?

LAFFLEUR, F.; KROUSKÁ, J.; TKACZ, J.; PEKAŘ, M.; AGHAI, F.; NETSOMBOON, K.

Original Title

Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?

English Title

Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?

Type

WoS Article

Original Abstract

This study was undertaken to prepare films by solvent evaporation method comprising well-known polymers in order to investigate their potential for buccal suitability. Mucoadhesive films were manufactured using different polymers such as ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose as well as carboxymethyl cellulose. Buccal films were evaluated in regards of mucoadhesiveness, swelling and physico-chemical properties. Furthermore rheological measurement and adhesion study were carried out on the buccal porcine mucosa. Moreover, allantoin as humectant was incorporated and trans-mucosal water loss was determined. The results showed that physico-chemical, buccal adhesive and swelling properties varied depending on the composition of the polymers. The findings indicated films containing allantoin to be suitable for buccal application. In completion, adhesive films are appropriate and promising formulations in the treatment of various disease in the intraoral cavity.

English abstract

This study was undertaken to prepare films by solvent evaporation method comprising well-known polymers in order to investigate their potential for buccal suitability. Mucoadhesive films were manufactured using different polymers such as ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose as well as carboxymethyl cellulose. Buccal films were evaluated in regards of mucoadhesiveness, swelling and physico-chemical properties. Furthermore rheological measurement and adhesion study were carried out on the buccal porcine mucosa. Moreover, allantoin as humectant was incorporated and trans-mucosal water loss was determined. The results showed that physico-chemical, buccal adhesive and swelling properties varied depending on the composition of the polymers. The findings indicated films containing allantoin to be suitable for buccal application. In completion, adhesive films are appropriate and promising formulations in the treatment of various disease in the intraoral cavity.

Keywords

Allantoin, buccal, cellulose, film, mucoadhesion.

Key words in English

Allantoin, buccal, cellulose, film, mucoadhesion.

Authors

LAFFLEUR, F.; KROUSKÁ, J.; TKACZ, J.; PEKAŘ, M.; AGHAI, F.; NETSOMBOON, K.

RIV year

2019

Released

25.10.2018

ISBN

0378-5173

Periodical

International Journal of Pharmaceutics

Volume

1-2

Number

550

State

Kingdom of the Netherlands

Pages from

309

Pages to

315

Pages count

7

URL

https://www.sciencedirect.com/science/article/pii/S0378517318306033#f0005

BibTex

@article{BUT149262,
  author="LAFFLEUR, F. and KROUSKÁ, J. and TKACZ, J. and PEKAŘ, M. and AGHAI, F. and NETSOMBOON, K.",
  title="Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?",
  journal="International Journal of Pharmaceutics",
  year="2018",
  volume="1-2",
  number="550",
  pages="309--315",
  doi="10.1016/j.ijpharm.2018.08.032",
  issn="0378-5173",
  url="https://www.sciencedirect.com/science/article/pii/S0378517318306033#f0005"
}