Publication result detail
p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system
PORUBIAKOVÁ, O.; BRÁZDA, V.; BOHÁLOVÁ, N.
Original Title
p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system
English Title
p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system
Type
Abstract
Original Abstract
Protein p53 is one of the most studied tumour suppressor proteins, plays important roles in regulating basic biological processes. The human p53 gene contains alternative promoters and thanks to alternative splicing could be expressed in several isoforms. P53 protein function is realized by DNA-binding and transactivation of target genes. In this paper results of p53alpha isoform DNA interaction studies by yeast isogenic system for in vivo transactivation studies in chromosomal context were presented.
English abstract
Protein p53 is one of the most studied tumour suppressor proteins, plays important roles in regulating basic biological processes. The human p53 gene contains alternative promoters and thanks to alternative splicing could be expressed in several isoforms. P53 protein function is realized by DNA-binding and transactivation of target genes. In this paper results of p53alpha isoform DNA interaction studies by yeast isogenic system for in vivo transactivation studies in chromosomal context were presented.
Keywords
p53alpha isoforms, yeast isogenic system, cruciforms
Key words in English
p53alpha isoforms, yeast isogenic system, cruciforms
Authors
PORUBIAKOVÁ, O.; BRÁZDA, V.; BOHÁLOVÁ, N.
Released
07.05.2019
BibTex
@misc{BUT157762,
author="Otília {Porubiaková} and Václav {Brázda} and Natália {Bohálová}",
title="p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system",
year="2019",
note="Abstract"
}