Publication detail

Problematic use of liquid chromatography for aminoclay-drug complexes

DUŠEK, J.

Original Title

Type

abstract

Language

English

Original Abstract

This study aimed to use modern liquid chromatography for the evaluation of an aminoclay-drug complex and also to determine the amount of drug in this complex. The aminoclay-drug complex is a relatively new system for drug delivery in the human body. This connection was already studied by meny types of analytical method with less or more successful results. The delivery matrix is based on organically modified aminoclay. magnesium phyllosilicate, which contains 3-aminopropyl groups. Because of these free groups, it is possible to have a bindingmolecule of the drug on the surface of complex. Aminoclay does not show signs of toxicity, and it has very good chemical, mechanical, and thermal stability, and it is also higly soluble in water. These properties lead to the expectation in an increase of bioavailability of drug in the human body with the use of the aminoclay-drug complex instead of free drug or other drug carriers. For verification of the binding drug, the method of liquid chromatography was already used with less or more successful results depends on use chromatography system, columns and last but not least on type of binding drug. There exist many problematic parts of sample preparation and analysis, which can lead to a devaluation of results. One of the problems is the different solubility of the aminoclay matrix and drug in water. The mobile phase is based on water. Therefore, the solubility of pure aminoclay and aminoclay-drug is very high, but there is problem when the drug is insoluble in water. The main problem is that pure aminoclay could be invisible for liquid chromatography. Therefore, the use of liquid chromatographyfor the verification of the binding drug on the aminoclay matrix and especially its amount in the complex is very limitless and, in some cases, totally unusale as direct method. In reference to that its open way to use liquid chromatography as indirect method how is descripted in this study.

Keywords

Liquid chromatography, aminoclay, drug

Authors

DUŠEK, J.

Released

30. 11. 2022

Publisher

Vysoké učení technické v Brně, Fakulta chemická

Location

Purkyňova 464/118, 61200 Brno

ISBN

978-80-214-6117-8

Edition number

první

Pages from

Pages to

Pages count

BibTex

@misc{BUT180747,
  author="Jakub {Dušek}",
  title="Problematic use of liquid chromatography for aminoclay-drug complexes",
  year="2022",
  edition="první",
  pages="35--35",
  publisher="Vysoké učení technické v Brně, Fakulta chemická",
  address="Purkyňova 464/118, 61200 Brno",
  isbn="978-80-214-6117-8",
  note="abstract"
}