Detail publikačního výsledku
Dried Blood Spot Self-Sampling with Automated Capillary Electrophoresis Processing for Clinical Analysis
RYŠAVÁ, L.; DVOŘÁK, M.; KUBÁŇ, P.
Original Title
Dried Blood Spot Self-Sampling with Automated Capillary Electrophoresis Processing for Clinical Analysis
English Title
Dried Blood Spot Self-Sampling with Automated Capillary Electrophoresis Processing for Clinical Analysis
Type
WoS Article
Original Abstract
A simple and convenient concept of blood sampling followed by a fully automated analysis is presented. A disposable sampling kit is used for accurate self-sampling of capillary blood from a finger prick. A high-throughput blood sampling is thus enabled, which is essential in many clinical assays and considerably improves life quality and comfort of involved subjects. The collected blood samples are mailed to a laboratory for a fully automated dried blood spot (DBS) processing and analysis, which are performed with a commercial capillary electrophoresis instrument. Quantitative results are obtained within 20 min from the DBS delivery to the laboratory. The presented concept is exemplified by the determination of warfarin blood concentrations and demonstrates excellent analytical performance. Moreover, this concept is generally applicable to a wide range of endogenous and exogenous blood compounds and represents a novel and attractive analytical tool for personalized health monitoring.
English abstract
A simple and convenient concept of blood sampling followed by a fully automated analysis is presented. A disposable sampling kit is used for accurate self-sampling of capillary blood from a finger prick. A high-throughput blood sampling is thus enabled, which is essential in many clinical assays and considerably improves life quality and comfort of involved subjects. The collected blood samples are mailed to a laboratory for a fully automated dried blood spot (DBS) processing and analysis, which are performed with a commercial capillary electrophoresis instrument. Quantitative results are obtained within 20 min from the DBS delivery to the laboratory. The presented concept is exemplified by the determination of warfarin blood concentrations and demonstrates excellent analytical performance. Moreover, this concept is generally applicable to a wide range of endogenous and exogenous blood compounds and represents a novel and attractive analytical tool for personalized health monitoring.
Keywords
analytical methods; blood self-sampling; dried blood spots; electrophoresis; warfarin
Key words in English
analytical methods; blood self-sampling; dried blood spots; electrophoresis; warfarin
Authors
RYŠAVÁ, L.; DVOŘÁK, M.; KUBÁŇ, P.
RIV year
2023
Released
08.03.2021
Publisher
WILEY-V C H VERLAG GMBH
Location
WEINHEIM
ISBN
1433-7851
Periodical
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume
60
Number
11
State
Federal Republic of Germany
Pages from
6068
Pages to
6075
Pages count
8
URL
Full text in the Digital Library
BibTex
@article{BUT182858,
author="Lenka {Ryšavá} and Miloš {Dvořák} and Pavel {Kubáň}",
title="Dried Blood Spot Self-Sampling with Automated Capillary Electrophoresis Processing for Clinical Analysis",
journal="ANGEWANDTE CHEMIE-INTERNATIONAL EDITION",
year="2021",
volume="60",
number="11",
pages="6068--6075",
doi="10.1002/anie.202012997",
issn="1433-7851",
url="https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202012997"
}