Publication detail

Comparison of Pharmacokinetic Models for Quantification of Blood-Brain-Barrier Opening Induced by Focused Ultrasound

HÝVLOVÁ, D. VITOUŠ, J. JIŘÍK, R.

Original Title

Comparison of Pharmacokinetic Models for Quantification of Blood-Brain-Barrier Opening Induced by Focused Ultrasound

Type

conference paper

Language

English

Original Abstract

This paper focuses on quantification of blood-brain barrier (BBB) opening induced by focused ultrasound. Dynamic contrast-enhanced MRI (DCE-MRI) with two different pharmacokinetic models, 2CX and ETK, is used to evaluate BBB opening. The ETK model is commonly used in BBB-opening studies. We propose use of a more advanced model, 2CX, that provides more accurate estimation of the BBB permeability. The accuracy of the models is compared using simulated and real data. The results demonstrate similar performance of the 2CX and ETK models in the brain region with a highly permeable BBB, but the ETK has proven unable to correctly detect low level of permeabilization. Thus, the 2CX model is more suitable for the studies of BBB permeability dynamics.

Keywords

DCE-MRI, perfusion analysis, simulation, focused ultrasound, BBB opening

Authors

HÝVLOVÁ, D.; VITOUŠ, J.; JIŘÍK, R.

Released

25. 4. 2023

Publisher

Brno University of Technology, Faculty of Electrical Engineering and Communication

Location

Brno

ISBN

978-80-214-6154-3

Book

Proceedings II of the 29th Conference STUDENT EEICT 2023 Selected papers

Edition

1

ISBN

2788-1334

Periodical

Proceedings II of the Conference STUDENT EEICT

State

Czech Republic

Pages from

133

Pages to

136

Pages count

4

URL

https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2023_sbornik_2_v2.pdf

BibTex

@inproceedings{BUT184508,
  author="Denisa {Hývlová} and Jiří {Vitouš} and Radovan {Jiřík}",
  title="Comparison of Pharmacokinetic Models for Quantification of Blood-Brain-Barrier Opening Induced by Focused Ultrasound",
  booktitle="Proceedings II of the 29th Conference STUDENT EEICT 2023 Selected papers",
  year="2023",
  series="1",
  journal="Proceedings II of the Conference STUDENT EEICT",
  pages="133--136",
  publisher="Brno University of Technology, Faculty of Electrical Engineering and Communication",
  address="Brno",
  doi="10.13164/eeict.2023.133",
  isbn="978-80-214-6154-3",
  issn="2788-1334",
  url="https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2023_sbornik_2_v2.pdf"
}