Detail publikace

Comparison of Pharmacokinetic Models for Quantification of Blood-Brain-Barrier Opening Induced by Focused Ultrasound

HÝVLOVÁ, D. VITOUŠ, J. JIŘÍK, R.

Originální název

Comparison of Pharmacokinetic Models for Quantification of Blood-Brain-Barrier Opening Induced by Focused Ultrasound

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

This paper focuses on quantification of blood-brain barrier (BBB) opening induced by focused ultrasound. Dynamic contrast-enhanced MRI (DCE-MRI) with two different pharmacokinetic models, 2CX and ETK, is used to evaluate BBB opening. The ETK model is commonly used in BBB-opening studies. We propose use of a more advanced model, 2CX, that provides more accurate estimation of the BBB permeability. The accuracy of the models is compared using simulated and real data. The results demonstrate similar performance of the 2CX and ETK models in the brain region with a highly permeable BBB, but the ETK has proven unable to correctly detect low level of permeabilization. Thus, the 2CX model is more suitable for the studies of BBB permeability dynamics.

Klíčová slova

DCE-MRI, perfusion analysis, simulation, focused ultrasound, BBB opening

Autoři

HÝVLOVÁ, D.; VITOUŠ, J.; JIŘÍK, R.

Vydáno

25. 4. 2023

Nakladatel

Brno University of Technology, Faculty of Electrical Engineering and Communication

Místo

Brno

ISBN

978-80-214-6154-3

Kniha

Proceedings II of the 29th Conference STUDENT EEICT 2023 Selected papers

Edice

1

ISSN

2788-1334

Periodikum

Proceedings II of the Conference STUDENT EEICT

Stát

Česká republika

Strany od

133

Strany do

136

Strany počet

4

URL

https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2023_sbornik_2_v2.pdf

BibTex

@inproceedings{BUT184508,
  author="Denisa {Hývlová} and Jiří {Vitouš} and Radovan {Jiřík}",
  title="Comparison of Pharmacokinetic Models for Quantification of Blood-Brain-Barrier Opening Induced by Focused Ultrasound",
  booktitle="Proceedings II of the 29th Conference STUDENT EEICT 2023 Selected papers",
  year="2023",
  series="1",
  journal="Proceedings II of the Conference STUDENT EEICT",
  pages="133--136",
  publisher="Brno University of Technology, Faculty of Electrical Engineering and Communication",
  address="Brno",
  doi="10.13164/eeict.2023.133",
  isbn="978-80-214-6154-3",
  issn="2788-1334",
  url="https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2023_sbornik_2_v2.pdf"
}