Detail publikačního výsledku
INTERACTION OF DRUGS WITH SOIL ORGANIC MATTER STUDIED BY MICROCALORIMETRY
KROUSKÁ, J.; PAPKO, N.; KLUČÁKOVÁ, M.
Original Title
INTERACTION OF DRUGS WITH SOIL ORGANIC MATTER STUDIED BY MICROCALORIMETRY
English Title
INTERACTION OF DRUGS WITH SOIL ORGANIC MATTER STUDIED BY MICROCALORIMETRY
Type
Paper in proceedings (conference paper)
Original Abstract
he usage of pharmaceuticals increases worldwide every year. The residues of these substances are excreted by the human or animal bodies and thus come into direct contact with the environment, mainly soils and ground water. The accumulation of pharmaceuticals in natural ecosystems may be problematic in the future therefore the knowledge of their behaviour, transport and interactions in the ecosystems is essential for their treatment. The most reactive substances in soils are humic as well as fulvic substances. Two fulvic acids stand as the model reactants with different pharmaceuticals in this study. These reactive compounds contain several kinds of active functional groups, such as hydrophilic hydroxylic or carboxylic groups, and also diverse hydrophobic structures. The interactions between fulvic acids and solutions of pure drugs were studied by isothermal titration calorimetry. The aim of the study was to observe the heat effects of the interactions and to describe the intensity of the binding process.
English abstract
he usage of pharmaceuticals increases worldwide every year. The residues of these substances are excreted by the human or animal bodies and thus come into direct contact with the environment, mainly soils and ground water. The accumulation of pharmaceuticals in natural ecosystems may be problematic in the future therefore the knowledge of their behaviour, transport and interactions in the ecosystems is essential for their treatment. The most reactive substances in soils are humic as well as fulvic substances. Two fulvic acids stand as the model reactants with different pharmaceuticals in this study. These reactive compounds contain several kinds of active functional groups, such as hydrophilic hydroxylic or carboxylic groups, and also diverse hydrophobic structures. The interactions between fulvic acids and solutions of pure drugs were studied by isothermal titration calorimetry. The aim of the study was to observe the heat effects of the interactions and to describe the intensity of the binding process.
Keywords
drug; Humic substances; interaction; microcalorimetry
Key words in English
drug; Humic substances; interaction; microcalorimetry
Authors
KROUSKÁ, J.; PAPKO, N.; KLUČÁKOVÁ, M.
RIV year
2024
Released
19.10.2022
ISBN
9788088365099
Book
NANOCON Conference Proceedings - International Conference on Nanomaterials
Pages from
255
Pages to
259
Pages count
5
URL
Full text in the Digital Library
BibTex
@inproceedings{BUT188090,
author="Jitka {Krouská} and Nadezhda {Papko} and Martina {Klučáková}",
title="INTERACTION OF DRUGS WITH SOIL ORGANIC MATTER STUDIED BY MICROCALORIMETRY",
booktitle="NANOCON Conference Proceedings - International Conference on Nanomaterials",
year="2022",
pages="255--259",
isbn="9788088365099",
url="https://www.scopus.com/record/display.uri?eid=2-s2.0-85151338657&origin=inward&txGid=5e734680b209dca37207e6bf854d0036"
}