Publication detail

Optimizing Hyaluronan-Based Lubricants for Treating Thoracolumbar Fascia Pathologies: Insights from Tribological and Pharmacokinetic Studies

STREĎANSKÁ, A. ŠIMEK, M. MATONOHOVÁ, J. NEČAS, D. VRBKA, M. SUCHÁNEK, J. PAVLIŇÁKOVÁ, V. VOJTOVÁ, L. HARTL, M. KŘUPKA, I. NEŠPOROVÁ, K.

Original Title

Optimizing Hyaluronan-Based Lubricants for Treating Thoracolumbar Fascia Pathologies: Insights from Tribological and Pharmacokinetic Studies

Type

journal article in Web of Science

Language

English

Original Abstract

In a world where the incidence of non-specific lower back pain (LBP) is steadily increasing, researchers are still searching for effective solutions for patients. Hyaluronic acid (HA) viscosupplementation is commonly used to restore lubrication in osteoarthritis (OA) and other medical applications, but its rapid metabolism limits efficacy. This study evaluates whether an HA derivative can replace native HA for the treatment of non-specific LBP while maintaining or enhancing its frictional properties and improving in vivo stability. Six HA-based lubricants, both native and derivatized, were tested in a tribological rabbit fascia model and a new synthetic model. Reduced HA derivative showed better tribological properties and longer in vivo residence time compared to native HA, as demonstrated in pharmacokinetic studies in rabbits. The 316 kDa HA and reduced HA exhibited the most stable tribological properties, which were influenced by their molecular weight and concentration. These findings suggest that both native and reduced HA are promising viscosupplements for intrafascial injection in the treatment of LBP, with reduced HA potentially enhancing effectiveness through a prolonged effect.

Keywords

lower back pain; hyaluronic acid; fascia; friction; viscosupplementation

Authors

STREĎANSKÁ, A.; ŠIMEK, M.; MATONOHOVÁ, J.; NEČAS, D.; VRBKA, M.; SUCHÁNEK, J.; PAVLIŇÁKOVÁ, V.; VOJTOVÁ, L.; HARTL, M.; KŘUPKA, I.; NEŠPOROVÁ, K.

Released

16. 4. 2025

Publisher

MDPI

Location

Switzerland (Švýcarsko)

ISBN

2075-4442

Periodical

Lubricants

Year of study

13

Number

4

State

Swiss Confederation

Pages from

1

Pages to

17

Pages count

17

URL

https://www.mdpi.com/2075-4442/13/4/184

Full text in the Digital Library

http://hdl.handle.net/11012/250893

BibTex

@article{BUT197716,
  author="Alexandra {Streďanská} and Matěj {Šimek} and Jana {Matonohová} and David {Nečas} and Martin {Vrbka} and Jakub {Suchánek} and Veronika {Pavliňáková} and Lucy {Vojtová} and Martin {Hartl} and Ivan {Křupka} and Kristina {Nešporová}",
  title="Optimizing Hyaluronan-Based Lubricants for Treating Thoracolumbar Fascia Pathologies: Insights from Tribological and Pharmacokinetic Studies",
  journal="Lubricants",
  year="2025",
  volume="13",
  number="4",
  pages="17",
  doi="10.3390/lubricants13040184",
  issn="2075-4442",
  url="https://www.mdpi.com/2075-4442/13/4/184"
}