Publication result detail
The assessment of contamination of selected river streams in the Czech Republic by human and veterinary drug residues with liquid and gas chromatography
LACINA, P.; DVOŘÁKOVÁ, P.; VÁVROVÁ, M.
Original Title
The assessment of contamination of selected river streams in the Czech Republic by human and veterinary drug residues with liquid and gas chromatography
English Title
The assessment of contamination of selected river streams in the Czech Republic by human and veterinary drug residues with liquid and gas chromatography
Type
Peer-reviewed article not indexed in WoS or Scopus
Original Abstract
This study monitors presence of selected drug residues in two rivers in the Czech Republic. High performance liquid chromatography with mass spectrometric detection (HPLC-MS) and comprehensive two-dimensional gas chromatography with mass spectrometric detection Time-of-Flight (GCxGC-TOF MS) are applied for determination of selected drug residues. HPLC-MS was used for determination of drugs from the group of sulfonamide antibiotics and GCxGC-TOF MS was used for determination of drugs from the group of non-steroidal anti-inflammatory drugs. Presence of selected contaminants was monitored in two rivers (the river Svratka and the river Svitava) in Moravia region in the Czech Republic. Samples were collected along the river streams in March 2011. Solid phase extraction (SPE) method was used for extraction and preconcentration of analytes. Limits of detection were ranged from 0.24 to 2.55 ug.L-1 for sulfonamides analysed by HPLC-MS and from 0.18 to 5 ng.L-1 for non-steroidal anti-inflammatory drugs analysed by GCxGC-TOF MS; both ranges depending on specific compound. On some sampling places were found following drugs: sulfapyridine, sulfamerazine, sulfamethazine, sulfamethoxazole with concentrations in units of ug.L-1 and salicylic acid, ibuprofen, caffeine, naproxen, ketoprofen and diclofenac with range of concentrations from units to hundreds of ng.L-1.
English abstract
This study monitors presence of selected drug residues in two rivers in the Czech Republic. High performance liquid chromatography with mass spectrometric detection (HPLC-MS) and comprehensive two-dimensional gas chromatography with mass spectrometric detection Time-of-Flight (GCxGC-TOF MS) are applied for determination of selected drug residues. HPLC-MS was used for determination of drugs from the group of sulfonamide antibiotics and GCxGC-TOF MS was used for determination of drugs from the group of non-steroidal anti-inflammatory drugs. Presence of selected contaminants was monitored in two rivers (the river Svratka and the river Svitava) in Moravia region in the Czech Republic. Samples were collected along the river streams in March 2011. Solid phase extraction (SPE) method was used for extraction and preconcentration of analytes. Limits of detection were ranged from 0.24 to 2.55 ug.L-1 for sulfonamides analysed by HPLC-MS and from 0.18 to 5 ng.L-1 for non-steroidal anti-inflammatory drugs analysed by GCxGC-TOF MS; both ranges depending on specific compound. On some sampling places were found following drugs: sulfapyridine, sulfamerazine, sulfamethazine, sulfamethoxazole with concentrations in units of ug.L-1 and salicylic acid, ibuprofen, caffeine, naproxen, ketoprofen and diclofenac with range of concentrations from units to hundreds of ng.L-1.
Keywords
drug residues; non-steroidal anti-inflammatory drugs; sulfonamide antibiotics; liquid chromatography; gas chromatography; surface water
Key words in English
drug residues; non-steroidal anti-inflammatory drugs; sulfonamide antibiotics; liquid chromatography; gas chromatography; surface water
Authors
LACINA, P.; DVOŘÁKOVÁ, P.; VÁVROVÁ, M.
RIV year
2013
Released
01.11.2012
ISBN
1018-4619
Periodical
Fresenius Environmental Bulletin
Volume
21
Number
11a
State
Federal Republic of Germany
Pages from
3318
Pages to
3324
Pages count
7
BibTex
@article{BUT95507,
author="Petr {Lacina} and Petra {Dvořáková} and Milada {Vávrová}",
title="The assessment of contamination of selected river streams in the Czech Republic by human and veterinary drug residues with liquid and gas chromatography",
journal="Fresenius Environmental Bulletin",
year="2012",
volume="21",
number="11a",
pages="3318--3324",
issn="1018-4619"
}