Publication result detail

Biotransformation of ferulic acid into vanillyl alcohol and vanillic acid employing thermophilic bacterium Caldimonas thermodepolymerans

HRABALOVÁ, V.; OPIAL, T.; MUSILOVÁ, J.; SEDLÁŘ, K.; OBRUČA, S.

Original Title

Biotransformation of ferulic acid into vanillyl alcohol and vanillic acid employing thermophilic bacterium Caldimonas thermodepolymerans

English Title

Biotransformation of ferulic acid into vanillyl alcohol and vanillic acid employing thermophilic bacterium Caldimonas thermodepolymerans

Type

WoS Article

Original Abstract

Caldimonas thermodepolymerans , a Gram -negative, moderately thermophilic bacterium, exhibits a remarkable biotechnological potential. Given the presence of genes in its genome dedicated to the metabolization of ferulic acid (FA), this study aimed to explore the bacterium 's capability for biotransforming FA into high -value metabolites. The results unequivocally demonstrate the bacterium 's proficiency in the efficient and rapid conversion of FA into vanillyl alcohol (VOH) and vanillic acid (VA). By manipulating key cultivation parameters, such as adjusting initial FA doses and varying cultivation periods, the product profile can be tailored. Higher initial doses and shorter cultivation periods favor the production of VOH, while lower FA doses and extended cultivation periods lead to the predominant formation of VA. Furthermore, the process can be operated in a repeated-batch scenario. This underscores the potential of C. thermodepolymerans for industrial biotransformation of FA, presenting a promising avenue for leveraging its capabilities in practical applications.

English abstract

Caldimonas thermodepolymerans , a Gram -negative, moderately thermophilic bacterium, exhibits a remarkable biotechnological potential. Given the presence of genes in its genome dedicated to the metabolization of ferulic acid (FA), this study aimed to explore the bacterium 's capability for biotransforming FA into high -value metabolites. The results unequivocally demonstrate the bacterium 's proficiency in the efficient and rapid conversion of FA into vanillyl alcohol (VOH) and vanillic acid (VA). By manipulating key cultivation parameters, such as adjusting initial FA doses and varying cultivation periods, the product profile can be tailored. Higher initial doses and shorter cultivation periods favor the production of VOH, while lower FA doses and extended cultivation periods lead to the predominant formation of VA. Furthermore, the process can be operated in a repeated-batch scenario. This underscores the potential of C. thermodepolymerans for industrial biotransformation of FA, presenting a promising avenue for leveraging its capabilities in practical applications.

Keywords

Caldimonas thermodepolymerans; Thermophiles; Ferulic acid; Biotransformation; Vanillic acid; Vanillyl alcohol

Key words in English

Caldimonas thermodepolymerans; Thermophiles; Ferulic acid; Biotransformation; Vanillic acid; Vanillyl alcohol

Authors

HRABALOVÁ, V.; OPIAL, T.; MUSILOVÁ, J.; SEDLÁŘ, K.; OBRUČA, S.

RIV year

2025

Released

02.09.2024

Publisher

ELSEVIER SCIENCE INCSTE 800, 230 PARK AVE, NEW YORK, NY 10169

ISBN

0141-0229

Periodical

ENZYME AND MICROBIAL TECHNOLOGY

Volume

179

Number

9

State

United States of America

Pages from

1

Pages to

6

Pages count

6

URL

https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S0141022924000826?via%3Dihub

BibTex

@article{BUT189077,
  author="Vendula {Hrabalová} and Tomáš {Opial} and Jana {Musilová} and Karel {Sedlář} and Stanislav {Obruča}",
  title="Biotransformation of ferulic acid into vanillyl alcohol and vanillic acid employing thermophilic bacterium Caldimonas thermodepolymerans",
  journal="ENZYME AND MICROBIAL TECHNOLOGY",
  year="2024",
  volume="179",
  number="9",
  pages="1--6",
  doi="10.1016/j.enzmictec.2024.110475",
  issn="0141-0229",
  url="https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S0141022924000826?via%3Dihub"
}