Detail publikačního výsledku
Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine
EL-SHAMY, I.; ABDEL-LATTIF, A.; FOUDA, M.; AL-DEYAB, S.; EL-HASHASH, M.
Original Title
Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine
English Title
Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine
Type
WoS Article
Original Abstract
1-Chloro-4-(2,4,6-trimethylphenyl)phthalazine (2) was used as a precursor for preparation of some novel pyrazolylphthalazine derivatives 6-13 and 15-19. Moreover, the acyclonucleosides 20-23 a-e were prepared by the reaction of hydrazinophthalazine derivative 3 with different aldoses. All new phthalazine derivatives were characterized using 1H NMR, 13C NMR, FTIR, mass spectrum and elemental analysis. The newly synthesized compounds showed highly activity against different species of bacteria and fungi, in addition to an excellent antiinflammatory property.
English abstract
1-Chloro-4-(2,4,6-trimethylphenyl)phthalazine (2) was used as a precursor for preparation of some novel pyrazolylphthalazine derivatives 6-13 and 15-19. Moreover, the acyclonucleosides 20-23 a-e were prepared by the reaction of hydrazinophthalazine derivative 3 with different aldoses. All new phthalazine derivatives were characterized using 1H NMR, 13C NMR, FTIR, mass spectrum and elemental analysis. The newly synthesized compounds showed highly activity against different species of bacteria and fungi, in addition to an excellent antiinflammatory property.
Keywords
C-nucleosides, Phthalazine derivatives, Biological activity
Key words in English
C-nucleosides, Phthalazine derivatives, Biological activity
Authors
EL-SHAMY, I.; ABDEL-LATTIF, A.; FOUDA, M.; AL-DEYAB, S.; EL-HASHASH, M.
Released
01.07.2014
ISBN
0970-7077
Periodical
ASIAN JOURNAL OF CHEMISTRY
Volume
26
Number
14
State
Republic of India
Pages from
4405
Pages to
4415
Pages count
11
Full text in the Digital Library
BibTex
@article{BUT112240,
author="Ibrahim E. {El-Shamy} and Abdelmohsen Moustafa {Abdellatif} and Moustafa M.D. {Fouda} and Salem S. {Al-Deyab} and Maher A. {El-Hashash}",
title="Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine",
journal="ASIAN JOURNAL OF CHEMISTRY",
year="2014",
volume="26",
number="14",
pages="4405--4415",
issn="0970-7077"
}