Detail publikačního výsledku

Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine

EL-SHAMY, I.; ABDEL-LATTIF, A.; FOUDA, M.; AL-DEYAB, S.; EL-HASHASH, M.

Originální název

Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine

Anglický název

Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine

Druh

Článek WoS

Originální abstrakt

1-Chloro-4-(2,4,6-trimethylphenyl)phthalazine (2) was used as a precursor for preparation of some novel pyrazolylphthalazine derivatives 6-13 and 15-19. Moreover, the acyclonucleosides 20-23 a-e were prepared by the reaction of hydrazinophthalazine derivative 3 with different aldoses. All new phthalazine derivatives were characterized using 1H NMR, 13C NMR, FTIR, mass spectrum and elemental analysis. The newly synthesized compounds showed highly activity against different species of bacteria and fungi, in addition to an excellent antiinflammatory property.

Anglický abstrakt

1-Chloro-4-(2,4,6-trimethylphenyl)phthalazine (2) was used as a precursor for preparation of some novel pyrazolylphthalazine derivatives 6-13 and 15-19. Moreover, the acyclonucleosides 20-23 a-e were prepared by the reaction of hydrazinophthalazine derivative 3 with different aldoses. All new phthalazine derivatives were characterized using 1H NMR, 13C NMR, FTIR, mass spectrum and elemental analysis. The newly synthesized compounds showed highly activity against different species of bacteria and fungi, in addition to an excellent antiinflammatory property.

Klíčová slova

C-nucleosides, Phthalazine derivatives, Biological activity

Klíčová slova v angličtině

C-nucleosides, Phthalazine derivatives, Biological activity

Autoři

EL-SHAMY, I.; ABDEL-LATTIF, A.; FOUDA, M.; AL-DEYAB, S.; EL-HASHASH, M.

Vydáno

01.07.2014

ISSN

0970-7077

Periodikum

ASIAN JOURNAL OF CHEMISTRY

Svazek

26

Číslo

14

Stát

Indická republika

Strany od

4405

Strany do

4415

Strany počet

11

Plný text v Digitální knihovně

http://hdl.handle.net/

BibTex

@article{BUT112240,
  author="Ibrahim E. {El-Shamy} and Abdelmohsen Moustafa {Abdellatif} and Moustafa M.D. {Fouda} and Salem S. {Al-Deyab} and Maher A. {El-Hashash}",
  title="Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine",
  journal="ASIAN JOURNAL OF CHEMISTRY",
  year="2014",
  volume="26",
  number="14",
  pages="4405--4415",
  issn="0970-7077"
}