Course detail

Engineering of Chemical-Pharmaceutical Production

FCH-MC_ICHVAcad. year: 2023/2024

The course provides theoretical and practical foundations of Particular systems and Powder technology applied for the production of pharmaceuticals.
Particle systems characterization, basic parameters of particulates and the measurement of them. Grain sizing and morphology of particulates.
Conveying and handling of particulates. Comminution, separation, homogenization, segregation, compaction, aglomeration, size enlargement, drying and thermal processes of particulates.
Surface properties of fine-particle materials, sorption, surface moisture. Suspension and dispersion formation. Surface treatment of particulates. Material handling, sampling and dosing. Bulk properties of particulates. Pumping and dosing of fluids. Basis of bulk storage, hoppers and feeders design. Powder Technology project planning and the production control fundamentals. Dust nuisance. Particulates and drug production, handling operating safety.

Language of instruction


Number of ECTS credits


Mode of study

Not applicable.

Entry knowledge

Chemical engineering I and II

Rules for evaluation and completion of the course

Examination in the oral form, knowledge in the given lectures extent is demanded.
Lectures on the most problematical points of the Powder Technology processes in the pharmaceutical industry. Permanently inovated lectures demand attending of students. Recommended literature and the main thesis of the lectures on www pages of Faculty of Chemistry is insufficient for the successfull exam.


General knowledge of students about the today´s Powder Technology science possibilities used in practice of pharmaceuticals production.
Basic knowledge of both Powder Technology theory and practice used in today´s pharmaceutical processes.

Study aids

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

Hanika J.: Farmaceutické inženýrství. VSCHT Praha, 2013. (CS)
Hovorka F.: Technologie chemických výrob. VŠCHT Praha, 2012. (CS)

Recommended reading

M. J. Rhodes: Principles of Powder Technology, John Wiley and sons, LTD, 1990 (EN)
Salman A.D., Ghadiri M., Hounslow M.J.: Handbook of Powder Technology, Volume 12, Elsevier, 2007. ISBN 978-0444530806
Masuda H., Higashitani K, Yoshida H.: Powder Technology Handbook, Third Edition, CRC Press, 2006. ISBN: 978-1574447828 H. Masuda, K. Higashitani, H. Yoshida, Taylor and Francis, 2006, ISBN-13: 978-1574447828

Classification of course in study plans

  • Programme NPCP_CHMA Master's

    specialization CHBL , 2. year of study, winter semester, compulsory-optional
    specialization BF , 2. year of study, winter semester, compulsory-optional

  • Programme NKCP_CHPL Master's, 2. year of study, winter semester, compulsory-optional
  • Programme NPCP_CHPL Master's, 2. year of study, winter semester, compulsory-optional

Type of course unit



26 hours, optionally

Teacher / Lecturer


1. Characterization of the particular systems , the basic parameters of the particular systems and their measurement. Grain size and morphology of the particle constituents of particulate systems.
2. Transportation, convaing and handling with particular systems. The issue of classification and separation .
3. The processes of disintegration, preparation of ultra-fine to nano - fine particulate systems.
4. Homogenization of powder systems, segregation, compaction, agglomeration, granulation, tabletting.
5. Drying and heat exposure of ultrafine particulate matter. Lyophilization .
6. Bulk properties of particulate systems, ways of the bulk properties measurement. Basis of bulk storage, hoppers, feeders and warehousing design.
7. Surface properties of fine-grained particulate matter , sorption properties , moisture transport and equilibrium moisture content of particulate matter.
8. Surface modification of powders. Surface treatment of solid dosage forms. Making the multi-layers systems.
9. Making suspensions and dispersions. Homogenization of liquids and pastes .
10. Sampling of particulate systems. Performance of solid dosage forms in containers , " blistering ", expedition .
11. The issue of transport, storage and dosing of liquid systems.
12. Specifics of measurement and control of chemical- pharmaceutical processes. The issue of planning , approval and implementation of new pharmaceutical processes.
13. Aspects of dust. Work safety with particular biological and chemical- active systems.

Guided consultation in combined form of studies

26 hours, optionally

Teacher / Lecturer