Course detail

Laboratory Classes in Organic Chemistry

FCH-BC_OCH_PAcad. year: 2023/2024

Practical teaching of the preparation, isolation, separation and identification of organic compounds based on specific one-step or multi-step syntheses. Acquisition of basic and expanding laboratory techniques used in the synthesis and subsequent isolation of organic substances. The student also has the opportunity to familiarize himself with the basics of separation techniques (thin-layer and column chromatography) and the method of structural identification of organic molecules using NMR spectroscopy

Language of instruction

Czech

Number of ECTS credits

Mode of study

Not applicable.

Guarantor

prof. Ing. Jozef Krajčovič, Ph.D.

Department

Institute of Chemistry and Technology of Environmental Protection (ÚCHTOŽP)

Entry knowledge

Not applicable.

Rules for evaluation and completion of the course

To obtain the credit, the student must:
Passing 11 jobs during the semester.
To master the theoretical principles of tasks.
Submit prepared and adjusted products.
Submit a fully developed laboratory protocols.;

Aims

The basis of the course is to enhance the adoption and expansion of basic laboratory methods and techniques (eg work at reduced temperatures, vacuum distillation, steam distillation) in the synthesis and analysis of organic compounds (determination of melting point, refractive index). Tasks are chosen so as to include the most common and most important types of chemical reactions discussed in hours of organic chemistry.
This course provides students especially the ability to:

Working with laboratory equipment and measuring instruments for conventional organic syntheses.
Experience with preaparation of organic substances in the laboratory scale.
Experience with occupational safety and health in the chemical laboratory work with organic compounds.

Study aids

Not applicable.

Prerequisites and corequisites

compulsory prerequisite
- Laboratory Classes in Inorganic Chemistry I

Basic literature

Keil B. a kol.: Laboratorní technika organické chemie, NČSAV, Praha 1963. (CS)
A.I.Vogel, A.R.Tatchell et al. Vogel's Textbook of Practical Organic Chemistry (5th Edition). Pearson publisher, 1996. (EN)

Type of course unit

Laboratory exercise

52 hours, compulsory

Teacher / Lecturer

Ing. Katsiaryna Arkhiptsava
Ing. Martin Cigánek, Ph.D.
Ing. Lucia Ivanová
Ing. Simona Kožnarová
prof. Ing. Jozef Krajčovič, Ph.D.
Ing. Jiří Lindovský
Mgr. Jan Richtár, Ph.D.
Ing. Jan Truksa, Ph.D.
Ing. Dominik Veselý
Ing. Jan Vespalec

Syllabus

As part of the first internship, training on organization, familiarization with individual tasks and safety in the organic laboratory is carried out. In the following weeks, students will complete the tasks below:

1. Laboratory safety training.
2. TLC basic technique for monitoring reaction progress, stationary phase, solvent effect.
3. Dibenzylideneacetone and β-nitrostyrene (condensation of aldehydes and ketones or nitroalkanes).
4. m-Dinitrobenzene (electrophilic aromatic substitution - nitration).
5. Ethyl acetate (Fischer esterification - reaction of carboxylic acid with alcohol).
6. Stilbene (Wittig reaction).
7. Benzoin (benzoin condensation of benzaldehyde catalyzed by thiamine).
8. Benzylidene(phenyl)amine and benzyl(phenyl)amine (reaction of carbonyl compound with amine - preparation of imine and its subsequent reduction to amine).
9. N-(4-Hydroxyphenyl)acetamide (Paracetamol) and N-(4-ethoxyphenyl)acetamide (Phenacetin) (preparation of carboxylic acid amide and Williamson's synthesis of ether).
10. 3-Nitroaniline (partial reduction of dinitro compound).
11. Diphenylmethanol (benzhydrol) (preparation of secondary alcohol by reaction of Grignard reagent with aldehyde).
12. Benzimidazole and benzotriazole (preparation of simple heterocycles).
13. The last week of the semester is reserved for make-ups for missed (due to illness) or unacknowledged (e.g., insufficient knowledge, yields, or failure to follow safety rules) syntheses of the above compounds.

Detailed instructions and readings for each assignment are available in the course elearning course.

eLearning

eLearning: currently opened course