Detail projektu

Directed evolution of polyhydroxyalkanoates producing bacteria

Období řešení: 01.01.2019 — 31.12.2021 Financování: Vnitřní projekty VUT

O projektu

The main goal of the project is to perform the evolutionary engineering of PHAs producing bacteria in order to better understand adaptive mechanisms of industrially relevant bacteria and to explore the role of PHAs in their adaptation to adverse conditions. Further, our aim is also to obtain robust bacterial strains resistant to the most important stress factors associated with anthropogenic and/or environmental stressors for in situ bioremediation as well as PHA producers adapted to microbial inhibitors present in lignocellulose-based substrates. To reach these goals, highly multidisciplinary approach combining various fields of science such as biochemistry, molecular biology, biophysics and also advanced techniques of microspectroscopy and cell manipulation will be applied.

Klíčová slova
evolutionary engineering; PHA; bacteria; stress response; adaptation

Označení

GA19-20697S

Originální jazyk

angličtina

Řešitelé

Obruča Stanislav, doc. Ing., Ph.D.
- hlavní řešitel (01.01.2019 - 31.12.2020)
Sedláček Petr, Ing., Ph.D.
- spoluřešitel (01.01.2019 - 31.12.2020)

Útvary

Centrum materiálového výzkumu
- příjemce (03.04.2018 - nezadáno)

Zdroje financování

Grantová agentura České republiky - Standardní projekty
- plně financující (01.01.2019 - 31.12.2021)

Výsledky

SEDLÁČEK, P.; SLANINOVÁ, E.; ENEV, V.; KOLLER,M.; NEBESÁŘOVÁ, J.; MÁROVÁ, I.; HRUBANOVÁ, K.; KRZYŽÁNEK, V.; SAMEK, O.; OBRUČA, S. What keeps polyhydroxyalkanoates in bacterial cells amorphous? A derivation from stress exposure experiments. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2019, vol. 103, no. 4, p. 1905-1917. ISSN: 0175-7598.
Detail

Odpovědnost: Ing. Marek Strakoš