Detail aplikovaného výsledku
Synthesis of paliperidone
Jiri Bartl, Petr Benovsky, Jozef Krajcovic
Originální název
Synthesis of paliperidone
Anglický název
Synthesis of paliperidone
Druh
Patent
Originální abstrakt
A 9-hydroxy or 9-acyloxy group can be added to a pyridopyrimidinone ring structure by a process comprising acylating a compound of formula (5) under Vilsmeier-Haack or Friedel-Crafts conditions to form a compound (6); and transforming with a peroxo-compound to obtain the compound (I). R represents hydrogen or a C1-C20 acyl group. The process is useful in the synthesis of paliperidone and derivatives.
Anglický abstrakt
A 9-hydroxy or 9-acyloxy group can be added to a pyridopyrimidinone ring structure by a process comprising acylating a compound of formula (5) under Vilsmeier-Haack or Friedel-Crafts conditions to form a compound (6); and transforming with a peroxo-compound to obtain the compound (I). R represents hydrogen or a C1-C20 acyl group. The process is useful in the synthesis of paliperidone and derivatives.
Číslo patentu
WO2009074333A1
Datum přihlášky
10.12.2008
Datum zápisu
18.06.2009
Vlastník
SYNTHON B.V. Microweg 22, NL-6545 CM Nijmegen
Licenční poplatek
K využití výsledku jiným subjektem je vždy nutné nabytí licence