Detail publikačního výsledku

Effect of a freeze drying method on the interactions between native hyalluronan and dyrophobic substances

MICHALICOVÁ, P.; PEKAŘ, M.; MRAVEC, F.

Originální název

Effect of a freeze drying method on the interactions between native hyalluronan and dyrophobic substances

Anglický název

Effect of a freeze drying method on the interactions between native hyalluronan and dyrophobic substances

Druh

Abstrakt

Originální abstrakt

Hyaluronan as a chemical with prevalent hydrophilic character in native form does not interact with hydrophobic species without additional support. The problem is that these areas are protected in the solution by probably highly organized molecules of water. The method of freeze-drying (lyophilization) was used in experimental part of this work to remove the water package and thereby making the binding sites available. Two fluorescence probes (perylene and prodan) were used as indicators of efficiency of interaction support. By monitoring of their specific fluorescence parameters the presence of desired interactions was judged. It was observed, that freeze-drying of the systems was effective way to support the interactions.

Anglický abstrakt

Hyaluronan as a chemical with prevalent hydrophilic character in native form does not interact with hydrophobic species without additional support. The problem is that these areas are protected in the solution by probably highly organized molecules of water. The method of freeze-drying (lyophilization) was used in experimental part of this work to remove the water package and thereby making the binding sites available. Two fluorescence probes (perylene and prodan) were used as indicators of efficiency of interaction support. By monitoring of their specific fluorescence parameters the presence of desired interactions was judged. It was observed, that freeze-drying of the systems was effective way to support the interactions.

Klíčová slova

native hyaluronan, freeze-drying, lyophilization, fluorescence probe

Klíčová slova v angličtině

native hyaluronan, freeze-drying, lyophilization, fluorescence probe

Autoři

MICHALICOVÁ, P.; PEKAŘ, M.; MRAVEC, F.

Rok RIV

2016

Vydáno

07.06.2015

Místo

Florencie

Kniha

Hyaluronan 2015

ISSN

NEUVEDENO

Strany od

177

Strany do

177

Strany počet

1

Plný text v Digitální knihovně

http://hdl.handle.net/

BibTex

@misc{BUT114946,
  author="Petra {Michalicová} and Miloslav {Pekař} and Filip {Mravec}",
  title="Effect of a freeze drying method on the interactions between native hyalluronan and dyrophobic substances",
  booktitle="Hyaluronan 2015",
  year="2015",
  pages="177--177",
  address="Florencie",
  note="Abstract"
}