Novel hydrogels based on natural polysaccharide Gum Karaya for soft tissue regeneration

Novel hydrogels based on natural polysaccharide Gum Karaya for soft tissue regeneration

Abstrakt

Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials. They are widely used in food and pharmaceutical industry. Moreover, polysaccharide based hydrogels are promising for use in medicine. They provide moist environment which stimulates faster wound healing. Hydrogels can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers). Gum Karaya (GK) is a natural polysaccharide obtained from Sterculia urens tree. GK is anionic polysaccharide containing β-D-galactose, L-rhamnose, β-D-glucuronic acid and Dgalacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ≈ 9 mil Da) insoluble in water. On the other hand, GK is biodegradable and cheap having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. Therefore, GK has good potential to be utilized in medicine. [1, 2] The objective of this study is preparation a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation meeting properties of wound healing coverings. Prepared samples were, characterized by SEM, FTIR, NMR, TGA, DSC and rheological evaluated.

Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials. They are widely used in food and pharmaceutical industry. Moreover, polysaccharide based hydrogels are promising for use in medicine. They provide moist environment which stimulates faster wound healing. Hydrogels can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers). Gum Karaya (GK) is a natural polysaccharide obtained from Sterculia urens tree. GK is anionic polysaccharide containing β-D-galactose, L-rhamnose, β-D-glucuronic acid and Dgalacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ≈ 9 mil Da) insoluble in water. On the other hand, GK is biodegradable and cheap having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. Therefore, GK has good potential to be utilized in medicine. [1, 2] The objective of this study is preparation a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation meeting properties of wound healing coverings. Prepared samples were, characterized by SEM, FTIR, NMR, TGA, DSC and rheological evaluated.

natural gum, polysaccharide, gum karaya, chemical modification, characterization, solubility

natural gum, polysaccharide, gum karaya, chemical modification, characterization, solubility

POŠTULKOVÁ, H.; NEDOMOVÁ, E.; VOJTOVÁ, L.; JANČÁŘ, J.

2016

23.04.2015

Masaryk University

Brno, Czech Republic

978-80-210-7825-3

CEITEC PHD RETREAT

112

112

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