Detail publikačního výsledku

Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic

VRÁNA, O.; NOVOHRADSKÝ, V.; MEDŘÍKOVÁ, Z.; BURDÍKOVÁ, J.; STUCHLÍKOVÁ, O.; KAŠPÁRKOVÁ, J.; BRABEC, V.

Originální název

Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic

Anglický název

Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic

Druh

Článek WoS

Originální abstrakt

Anticancer therapy by platinum complexes, based on nanocarrier-based delivery, may offer a new approach to improve the efficacy and tolerability of the platinum family of anticancer drugs. The original rules for the design of new anticancer platinum drugs were affected by the fact that, although cisplatin (cis-[PtCl2(NH3)2) was an anticancer drug, its isomer transplatin was not cytotoxic. For the first time, it is demonstrated that simple encapsulation of an inactive platinum compound in phospholipid bilayers transforms it into an efficient cytotoxic agent. Notably, the encapsulation of transplatin makes it possible to overcome the resistence mechanisms operating in cancer cells treated with cisplatin and prevents inactivation of transplatin in the extracellular environment. It is also shown that transplatin delivered to the cells in nanocapsules, in contrast to free (nonencapsulated) complex, forms cytotoxic cross-links on DNA.

Anglický abstrakt

Anticancer therapy by platinum complexes, based on nanocarrier-based delivery, may offer a new approach to improve the efficacy and tolerability of the platinum family of anticancer drugs. The original rules for the design of new anticancer platinum drugs were affected by the fact that, although cisplatin (cis-[PtCl2(NH3)2) was an anticancer drug, its isomer transplatin was not cytotoxic. For the first time, it is demonstrated that simple encapsulation of an inactive platinum compound in phospholipid bilayers transforms it into an efficient cytotoxic agent. Notably, the encapsulation of transplatin makes it possible to overcome the resistence mechanisms operating in cancer cells treated with cisplatin and prevents inactivation of transplatin in the extracellular environment. It is also shown that transplatin delivered to the cells in nanocapsules, in contrast to free (nonencapsulated) complex, forms cytotoxic cross-links on DNA.

Klíčová slova

Cancer; DNA; liposomes; phospholipids; platinum

Klíčová slova v angličtině

Cancer; DNA; liposomes; phospholipids; platinum

Autoři

VRÁNA, O.; NOVOHRADSKÝ, V.; MEDŘÍKOVÁ, Z.; BURDÍKOVÁ, J.; STUCHLÍKOVÁ, O.; KAŠPÁRKOVÁ, J.; BRABEC, V.

Rok RIV

2017

Vydáno

20.01.2016

Nakladatel

Wiley-VCH Verlag GmbH & Co. KGaA

Místo

Weinheim

ISSN

0947-6539

Periodikum

CHEMISTRY-A EUROPEAN JOURNAL

Svazek

22

Číslo

1

Stát

Spolková republika Německo

Strany od

2728

Strany do

2735

Strany počet

8

BibTex

@article{BUT122264,
  author="Oldřich {Vrána} and Vojtěch {Novohradský} and Zdenka {Medříková} and Jana {Burdíková} and Olga {Stuchlíková} and Jana {Kašpárková} and Viktor {Brabec}",
  title="Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic",
  journal="CHEMISTRY-A EUROPEAN JOURNAL",
  year="2016",
  volume="22",
  number="1",
  pages="2728--2735",
  doi="10.1002/chem.201504671",
  issn="0947-6539"
}