Detail publikačního výsledku
Characterization of the Colloidal Properties of a Microbubble Contrast Agent
PILGROVÁ, T.; ŘÍKOVSKÁ, K.; PEKAŘ, M.
Originální název
Characterization of the Colloidal Properties of a Microbubble Contrast Agent
Anglický název
Characterization of the Colloidal Properties of a Microbubble Contrast Agent
Druh
Stať ve sborníku v databázi WoS či Scopus
Originální abstrakt
Microbubbles are used as contrast agents in combination with ultrasound mostly for cardiovascular imaging and the assessment of perfusion of various organs and tumors. These systems are currently proposed for drug delivery applications. In the development process of a new contrast agent or drug delivery system is necessary to know colloidal properties of the system such as size distribution of microbubbles, phase stability of the system or progress of microbubble formation process. The aim of our study was to evaluate mentioned properties of contrast agent SonoVue® and analogous phospholipid systems. Systems were studied using spectroscopic methods including UV-VIS spectroscopy and dynamic light scattering technique. Microbubble formation process was investigated by means of maximum bubble pressure tensiometry. It was found that surface activity as well as composition of the system is significant for microbubble formation process. Dynamic light scattering method shows that size of SonoVue® microbubble is about 1000 nm but size distribution of the analogous system is larger which implies that preparation method influence final properties of the studied system
Anglický abstrakt
Microbubbles are used as contrast agents in combination with ultrasound mostly for cardiovascular imaging and the assessment of perfusion of various organs and tumors. These systems are currently proposed for drug delivery applications. In the development process of a new contrast agent or drug delivery system is necessary to know colloidal properties of the system such as size distribution of microbubbles, phase stability of the system or progress of microbubble formation process. The aim of our study was to evaluate mentioned properties of contrast agent SonoVue® and analogous phospholipid systems. Systems were studied using spectroscopic methods including UV-VIS spectroscopy and dynamic light scattering technique. Microbubble formation process was investigated by means of maximum bubble pressure tensiometry. It was found that surface activity as well as composition of the system is significant for microbubble formation process. Dynamic light scattering method shows that size of SonoVue® microbubble is about 1000 nm but size distribution of the analogous system is larger which implies that preparation method influence final properties of the studied system
Klíčová slova
microbubble, contrast agent, colloidal properties, size distribution, tensiometry
Klíčová slova v angličtině
microbubble, contrast agent, colloidal properties, size distribution, tensiometry
Autoři
PILGROVÁ, T.; ŘÍKOVSKÁ, K.; PEKAŘ, M.
Rok RIV
2017
Vydáno
03.12.2015
Nakladatel
Vysoké učení technické v Brně, Fakulta chemická
Místo
Purkyňova 464/118, 612 00 Brno
ISBN
978-80-214-5290-9
Kniha
Studentská odborná konference Chemie je život 2015 Sborník příspěvků
Strany od
289
Strany do
294
Strany počet
6
URL
Plný text v Digitální knihovně
BibTex
@inproceedings{BUT127432,
author="Tereza {Pilgrová} and Klára {Říkovská} and Miloslav {Pekař}",
title="Characterization of the Colloidal Properties of a Microbubble Contrast Agent",
booktitle="Studentská odborná konference Chemie je život 2015
Sborník příspěvků",
year="2015",
number="první",
pages="289--294",
publisher="Vysoké učení technické v Brně, Fakulta chemická",
address="Purkyňova 464/118, 612 00 Brno",
isbn="978-80-214-5290-9",
url="http://www.fch.vutbr.cz/media/sok/sbornik_prispevku_2015.pdf"
}