Detail publikačního výsledku

N-acetylglucoseamine as a signalling molecule triggering hyaluronic acid increase in streptococcus zooepidemicus

Lukáš Franke, Stanislav Pepeliaev, Radka Hrudíková, Zbyněk Černý, Dzinais Smirnou, Vladimír Velebný

Originální název

N-acetylglucoseamine as a signalling molecule triggering hyaluronic acid increase in streptococcus zooepidemicus

Anglický název

N-acetylglucoseamine as a signalling molecule triggering hyaluronic acid increase in streptococcus zooepidemicus

Druh

Abstrakt

Originální abstrakt

Hyaluronic acid is a linear polysaccharide composed of alternating D-glucuronic acid and N-acetylglucoseamine (GlcNAc) linked by beta(1, 4) and beta(1, 3) glycosidi bonds. Industrially, HA has been manufactured by fermentation of group C streptococci since the 1980s. HA is produced by processive synthase from the activated precursors UDP-glucuronic acid and UDP-N-Acetylglucoseamin. It was found that external supplementation by GlcNAc can increase HA production and its molecular weight. The aim of this study was to evaluate whether external GlcNAc acts as a direct substrate for hyaluronic acid biosynthesis or it works by different mechanism.

Anglický abstrakt

Hyaluronic acid is a linear polysaccharide composed of alternating D-glucuronic acid and N-acetylglucoseamine (GlcNAc) linked by beta(1, 4) and beta(1, 3) glycosidi bonds. Industrially, HA has been manufactured by fermentation of group C streptococci since the 1980s. HA is produced by processive synthase from the activated precursors UDP-glucuronic acid and UDP-N-Acetylglucoseamin. It was found that external supplementation by GlcNAc can increase HA production and its molecular weight. The aim of this study was to evaluate whether external GlcNAc acts as a direct substrate for hyaluronic acid biosynthesis or it works by different mechanism.

Klíčová slova

N-acetylglucoseamin, hyaluronic acid, precursor, supplementation

Klíčová slova v angličtině

N-acetylglucoseamin, hyaluronic acid, precursor, supplementation

Autoři

Lukáš Franke, Stanislav Pepeliaev, Radka Hrudíková, Zbyněk Černý, Dzinais Smirnou, Vladimír Velebný

Rok RIV

2017

Vydáno

03.07.2016

Nakladatel

New Biotechnology

Místo

Krakow, Poland

ISSN

1871-6784

Periodikum

New Biotechnology

Svazek

33

Číslo

S

Stát

Nizozemsko

Strany od

151

Strany do

151

Strany počet

1

URL

http://dx.doi.org/10.1016/j.nbt.2016.06.1248

BibTex

@misc{BUT128961,
  author="Radka {Hrudíková}",
  title="N-acetylglucoseamine as a signalling molecule triggering hyaluronic acid increase in streptococcus zooepidemicus",
  year="2016",
  journal="New Biotechnology",
  volume="33",
  number="S",
  pages="151--151",
  publisher="New Biotechnology",
  address="Krakow, Poland",
  doi="10.1016/j.nbt.2016.06.1248",
  issn="1871-6784",
  url="http://dx.doi.org/10.1016/j.nbt.2016.06.1248",
  note="Abstract"
}