Detail publikačního výsledku

Fluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic species

MICHALICOVÁ, P.; MRAVEC, F.; PEKAŘ, M.

Originální název

Fluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic species

Anglický název

Fluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic species

Druh

Článek WoS

Originální abstrakt

A freeze-drying method enabling solubilization of hydrophobic species in aqueous solutions of native hyaluronan is described. The method is based on opening the access to supposed hydrophobic patches on hyaluronan by disturbing its massive hydration shell. Hydrophobic and/or polarity-sensitive fluorescence probes were used as hydrophobic models or indicators of interactions with hydrophobic patches. Fluorescence parameters specific to individual probes confirmed the efficiency of the freeze-drying method. This work is the first step in developing biocompatible and biodegradable carriers for hydrophobic drugs with targeted distribution of the active compound from native, chemically non-modified hyaluronan.

Anglický abstrakt

A freeze-drying method enabling solubilization of hydrophobic species in aqueous solutions of native hyaluronan is described. The method is based on opening the access to supposed hydrophobic patches on hyaluronan by disturbing its massive hydration shell. Hydrophobic and/or polarity-sensitive fluorescence probes were used as hydrophobic models or indicators of interactions with hydrophobic patches. Fluorescence parameters specific to individual probes confirmed the efficiency of the freeze-drying method. This work is the first step in developing biocompatible and biodegradable carriers for hydrophobic drugs with targeted distribution of the active compound from native, chemically non-modified hyaluronan.

Klíčová slova

fluorescence; freeze-drying; hyaluronan; solubilization

Klíčová slova v angličtině

fluorescence; freeze-drying; hyaluronan; solubilization

Autoři

MICHALICOVÁ, P.; MRAVEC, F.; PEKAŘ, M.

Rok RIV

2018

Vydáno

03.10.2017

Nakladatel

PLOS

ISSN

1932-6203

Periodikum

PLoS One

Svazek

12

Číslo

9

Stát

Spojené státy americké

Strany od

1

Strany do

13

Strany počet

13

URL

http://europepmc.org/articles/PMC5590968?pdf=render

Plný text v Digitální knihovně

http://hdl.handle.net/11012/84116

BibTex

@article{BUT141013,
  author="Petra {Michalicová} and Filip {Mravec} and Miloslav {Pekař}",
  title="Fluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic species",
  journal="PLoS One",
  year="2017",
  volume="12",
  number="9",
  pages="1--13",
  doi="10.1371/journal.pone.0184558",
  issn="1932-6203",
  url="http://europepmc.org/articles/PMC5590968?pdf=render"
}

Dokumenty

journal.pone.0184558