Detail publikačního výsledku

Hyaluronan hydrogels modified by glycinated Kraft lignin: Morphology, swelling, viscoelastic properties and biocompatibility

Lenka Musilová, Aleš Mráček, Adriana Kovalcik, Petr Smolka, Antonín Minařík, Petr Humpolíček, Robert Vícha, Petr Ponížil

Originální název

Hyaluronan hydrogels modified by glycinated Kraft lignin: Morphology, swelling, viscoelastic properties and biocompatibility

Anglický název

Hyaluronan hydrogels modified by glycinated Kraft lignin: Morphology, swelling, viscoelastic properties and biocompatibility

Druh

Článek WoS

Originální abstrakt

Effects of the addition of water soluble glycinated Kraft lignin (WS/KL) on the mechanical stability and biocompatibility of hyaluronan (NaHy) hydrogels were evaluated in this work. Water soluble lignin was obtained by the modification of Kraft lignin via a Mannich reaction. It was found that WS/KL is highly compatible with hyaluronan due to its improved water solubility, which favours its use in designing new advanced composite hydrogels. The effects of the concentration of WS/KL on morphological, swelling and creep/recovery behaviours of hyaluronan hydrogels were investigated. It was detected that the creep resistance and creep recovery of NaHy hydrogels was improved by the incorporation of up to 3% (w/w) of WS/KL. In contrast, the swelling capacity of hydrogels was decreased. The cytotoxicity tests proved that glycinated KL lignin limits the viability of cells only slightly, and the final hyaluronan/lignin hydrogels were non-toxic materials.

Anglický abstrakt

Effects of the addition of water soluble glycinated Kraft lignin (WS/KL) on the mechanical stability and biocompatibility of hyaluronan (NaHy) hydrogels were evaluated in this work. Water soluble lignin was obtained by the modification of Kraft lignin via a Mannich reaction. It was found that WS/KL is highly compatible with hyaluronan due to its improved water solubility, which favours its use in designing new advanced composite hydrogels. The effects of the concentration of WS/KL on morphological, swelling and creep/recovery behaviours of hyaluronan hydrogels were investigated. It was detected that the creep resistance and creep recovery of NaHy hydrogels was improved by the incorporation of up to 3% (w/w) of WS/KL. In contrast, the swelling capacity of hydrogels was decreased. The cytotoxicity tests proved that glycinated KL lignin limits the viability of cells only slightly, and the final hyaluronan/lignin hydrogels were non-toxic materials.

Klíčová slova

Hyaluronan Lignin Hydrogel Swelling behaviour Mechanical properties Biocompatibility of hydrogels

Klíčová slova v angličtině

Hyaluronan Lignin Hydrogel Swelling behaviour Mechanical properties Biocompatibility of hydrogels

Autoři

Lenka Musilová, Aleš Mráček, Adriana Kovalcik, Petr Smolka, Antonín Minařík, Petr Humpolíček, Robert Vícha, Petr Ponížil

Rok RIV

2019

Vydáno

01.01.2018

Nakladatel

Elsevier

Místo

Amsterdam

ISSN

1879-1344

Periodikum

Carbohydrate Polymers

Svazek

181

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

394

Strany do

403

Strany počet

10

URL

http://www.sciencedirect.com/science/article/pii/S0144861717311918

BibTex

@article{BUT141040,
  author="Adriána {Kovalčík}",
  title="Hyaluronan hydrogels modified by glycinated Kraft lignin: Morphology,
swelling, viscoelastic properties and biocompatibility",
  journal="Carbohydrate Polymers",
  year="2018",
  volume="181",
  number="1",
  pages="394--403",
  doi="10.1016/j.carbpol.2017.10.048",
  issn="0144-8617",
  url="http://www.sciencedirect.com/science/article/pii/S0144861717311918"
}