Detail publikačního výsledku

Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?

LAFFLEUR, F.; KROUSKÁ, J.; TKACZ, J.; PEKAŘ, M.; AGHAI, F.; NETSOMBOON, K.

Originální název

Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?

Anglický název

Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?

Druh

Článek WoS

Originální abstrakt

This study was undertaken to prepare films by solvent evaporation method comprising well-known polymers in order to investigate their potential for buccal suitability. Mucoadhesive films were manufactured using different polymers such as ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose as well as carboxymethyl cellulose. Buccal films were evaluated in regards of mucoadhesiveness, swelling and physico-chemical properties. Furthermore rheological measurement and adhesion study were carried out on the buccal porcine mucosa. Moreover, allantoin as humectant was incorporated and trans-mucosal water loss was determined. The results showed that physico-chemical, buccal adhesive and swelling properties varied depending on the composition of the polymers. The findings indicated films containing allantoin to be suitable for buccal application. In completion, adhesive films are appropriate and promising formulations in the treatment of various disease in the intraoral cavity.

Anglický abstrakt

This study was undertaken to prepare films by solvent evaporation method comprising well-known polymers in order to investigate their potential for buccal suitability. Mucoadhesive films were manufactured using different polymers such as ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose as well as carboxymethyl cellulose. Buccal films were evaluated in regards of mucoadhesiveness, swelling and physico-chemical properties. Furthermore rheological measurement and adhesion study were carried out on the buccal porcine mucosa. Moreover, allantoin as humectant was incorporated and trans-mucosal water loss was determined. The results showed that physico-chemical, buccal adhesive and swelling properties varied depending on the composition of the polymers. The findings indicated films containing allantoin to be suitable for buccal application. In completion, adhesive films are appropriate and promising formulations in the treatment of various disease in the intraoral cavity.

Klíčová slova

Allantoin, buccal, cellulose, film, mucoadhesion.

Klíčová slova v angličtině

Allantoin, buccal, cellulose, film, mucoadhesion.

Autoři

LAFFLEUR, F.; KROUSKÁ, J.; TKACZ, J.; PEKAŘ, M.; AGHAI, F.; NETSOMBOON, K.

Rok RIV

2019

Vydáno

25.10.2018

ISSN

0378-5173

Periodikum

International Journal of Pharmaceutics

Svazek

1-2

Číslo

550

Stát

Nizozemsko

Strany od

309

Strany do

315

Strany počet

7

URL

https://www.sciencedirect.com/science/article/pii/S0378517318306033#f0005

Plný text v Digitální knihovně

http://hdl.handle.net/

BibTex

@article{BUT149262,
  author="LAFFLEUR, F. and KROUSKÁ, J. and TKACZ, J. and PEKAŘ, M. and AGHAI, F. and NETSOMBOON, K.",
  title="Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?",
  journal="International Journal of Pharmaceutics",
  year="2018",
  volume="1-2",
  number="550",
  pages="309--315",
  doi="10.1016/j.ijpharm.2018.08.032",
  issn="0378-5173",
  url="https://www.sciencedirect.com/science/article/pii/S0378517318306033#f0005"
}