Detail publikačního výsledku
Fabrication of novel PHB-liposome nanoparticles and study of their toxicity in vitro
BOKROVÁ, J.; MÁROVÁ, I.; MATOUŠKOVÁ, P.; PAVELKOVÁ, R.
Originální název
Fabrication of novel PHB-liposome nanoparticles and study of their toxicity in vitro
Anglický název
Fabrication of novel PHB-liposome nanoparticles and study of their toxicity in vitro
Druh
Článek WoS
Originální abstrakt
n this work, novel combined PHB-liposome nanoparticles were synthesized and characterized, and their biocompatability with mammalian cells was assessed in vitro. Incorporation of PHB into liposome particles led to preservation of small size (123.8 ± 0.9 nm; evaluated by DLS) and colloidal stability of particles for 2 months in water environment. Cytotoxicity studies using MTT test with two different skin keratinocytes cell lines (HEK and HaCaT) showed significant dose-dependent differences in cell viability after exposure to liposome and PHB liposome particles in vitro.
Anglický abstrakt
n this work, novel combined PHB-liposome nanoparticles were synthesized and characterized, and their biocompatability with mammalian cells was assessed in vitro. Incorporation of PHB into liposome particles led to preservation of small size (123.8 ± 0.9 nm; evaluated by DLS) and colloidal stability of particles for 2 months in water environment. Cytotoxicity studies using MTT test with two different skin keratinocytes cell lines (HEK and HaCaT) showed significant dose-dependent differences in cell viability after exposure to liposome and PHB liposome particles in vitro.
Klíčová slova
nanoparticles, PHB-liposome, cytotoxicity
Klíčová slova v angličtině
nanoparticles, PHB-liposome, cytotoxicity
Autoři
BOKROVÁ, J.; MÁROVÁ, I.; MATOUŠKOVÁ, P.; PAVELKOVÁ, R.
Rok RIV
2019
Vydáno
11.02.2019
Nakladatel
Springer Verlag, SRN
Místo
SRN
ISSN
1572-896X
Periodikum
JOURNAL OF NANOPARTICLE RESEARCH
Svazek
2
Číslo
3
Stát
Nizozemsko
Strany od
3
Strany do
11
Strany počet
8
BibTex
@article{BUT155931,
author="Jitka {Bokrová} and Ivana {Márová} and Petra {Skoumalová} and Renata {Uhlířová}",
title="Fabrication of novel PHB-liposome nanoparticles and study of their toxicity in vitro",
journal="JOURNAL OF NANOPARTICLE RESEARCH",
year="2019",
volume="2",
number="3",
pages="3--11",
doi="10.1007/s11051-019-4484-7",
issn="1388-0764"
}