Detail publikačního výsledku

STUDY OF FLOW PROPERTIES OF POWDERS IN PHARMACEUTICAL INDUSTRY

KOLESA, P.; KLUČÁKOVÁ, M.; GAVENDA, A.

Originální název

STUDY OF FLOW PROPERTIES OF POWDERS IN PHARMACEUTICAL INDUSTRY

Anglický název

STUDY OF FLOW PROPERTIES OF POWDERS IN PHARMACEUTICAL INDUSTRY

Druh

Stať ve sborníku mimo WoS a Scopus

Originální abstrakt

The main purpose of presented work is study of two model batches of APIs which were characterized by different flow properties (especially different tendency to caking). Immunosuppressant drug Mycophenolic Acid (MPA) was chosen such as model substance for this study, because this API caused large troubles in production due to presence of large lumps which clogged the hopper and it was very difficult to transport the sample through the pipeline. This issue had an adverse impact on production efficiency and it was necessary to find the relevant properties and parameters which affect lumps creation. Therefore many physico-chemical techniques were used for characterization of chosen batches of MPA.

Anglický abstrakt

The main purpose of presented work is study of two model batches of APIs which were characterized by different flow properties (especially different tendency to caking). Immunosuppressant drug Mycophenolic Acid (MPA) was chosen such as model substance for this study, because this API caused large troubles in production due to presence of large lumps which clogged the hopper and it was very difficult to transport the sample through the pipeline. This issue had an adverse impact on production efficiency and it was necessary to find the relevant properties and parameters which affect lumps creation. Therefore many physico-chemical techniques were used for characterization of chosen batches of MPA.

Klíčová slova

API; flowability; caking; polymorphism; handling

Klíčová slova v angličtině

API; flowability; caking; polymorphism; handling

Autoři

KOLESA, P.; KLUČÁKOVÁ, M.; GAVENDA, A.

Rok RIV

2019

Vydáno

11.12.2018

Nakladatel

Czech Chemical Society

Místo

Prague

ISBN

2336-7210

Kniha

Czech Chemical Society Symposium Series

ISSN

2336-7210

Periodikum

Czech Chemical Society Symposium Series

Svazek

16

Číslo

6

Stát

Česká republika

Strany od

498

Strany do

503

Strany počet

528

URL

http://www.ccsss.cz/index.php/ccsss/issue/view/18/showToc

Plný text v Digitální knihovně

http://hdl.handle.net/

BibTex

@inproceedings{BUT156062,
  author="Pavel {Kolesa} and Martina {Klučáková} and Aleš {Gavenda}",
  title="STUDY OF FLOW PROPERTIES OF POWDERS IN PHARMACEUTICAL INDUSTRY",
  booktitle="Czech Chemical Society Symposium Series",
  year="2018",
  journal="Czech Chemical Society Symposium Series",
  volume="16",
  number="6",
  pages="498--503",
  publisher="Czech Chemical Society",
  address="Prague",
  isbn="2336-7210",
  issn="2336-7210",
  url="http://www.ccsss.cz/index.php/ccsss/issue/view/18/showToc"
}