Detail publikačního výsledku
The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria
BARTAS, M.; ČUTOVÁ, M.; BRÁZDA, V.; KAURA, P.; ŠŤASTNÝ, J.; KOLOMAZNÍK, J.; COUFAL, J.; GOSWAMI, P.; ČERVEŇ, J.; PEČINKA, P.
Originální název
The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria
Anglický název
The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria
Druh
Článek WoS
Originální abstrakt
The role of local DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, the significance of G-quadruplexes was demonstrated in the last decade, and their presence and functional relevance has been demonstrated in many genomes, including humans. In this study, we analyzed the presence and locations of G-quadruplex-forming sequences by G4Hunter in all complete bacterial genomes available in the NCBI database. G-quadruplex-forming sequences were identified in all species, however the frequency differed significantly across evolutionary groups. The highest frequency of G-quadruplex forming sequences was detected in the subgroup Deinococcus-Thermus, and the lowest frequency in Thermotogae. G-quadruplex forming sequences are non-randomly distributed and are favored in various evolutionary groups. G-quadruplex-forming sequences are enriched in ncRNA segments followed by mRNAs. Analyses of surrounding sequences showed G-quadruplex-forming sequences around tRNA and regulatory sequences. These data point to the unique and non-random localization of G-quadruplex-forming sequences in bacterial genomes.
Anglický abstrakt
The role of local DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, the significance of G-quadruplexes was demonstrated in the last decade, and their presence and functional relevance has been demonstrated in many genomes, including humans. In this study, we analyzed the presence and locations of G-quadruplex-forming sequences by G4Hunter in all complete bacterial genomes available in the NCBI database. G-quadruplex-forming sequences were identified in all species, however the frequency differed significantly across evolutionary groups. The highest frequency of G-quadruplex forming sequences was detected in the subgroup Deinococcus-Thermus, and the lowest frequency in Thermotogae. G-quadruplex forming sequences are non-randomly distributed and are favored in various evolutionary groups. G-quadruplex-forming sequences are enriched in ncRNA segments followed by mRNAs. Analyses of surrounding sequences showed G-quadruplex-forming sequences around tRNA and regulatory sequences. These data point to the unique and non-random localization of G-quadruplex-forming sequences in bacterial genomes.
Klíčová slova
G-quadruplex; bacteria; bioinformatics; deinococcus; G4Hunter
Klíčová slova v angličtině
G-quadruplex; bacteria; bioinformatics; deinococcus; G4Hunter
Autoři
BARTAS, M.; ČUTOVÁ, M.; BRÁZDA, V.; KAURA, P.; ŠŤASTNÝ, J.; KOLOMAZNÍK, J.; COUFAL, J.; GOSWAMI, P.; ČERVEŇ, J.; PEČINKA, P.
Rok RIV
2019
Vydáno
02.05.2019
ISSN
1420-3049
Periodikum
MOLECULES
Svazek
24
Číslo
9
Stát
Švýcarská konfederace
Strany od
1
Strany do
13
Strany počet
13
URL
Plný text v Digitální knihovně
BibTex
@article{BUT156781,
author="BARTAS, M. and ČUTOVÁ, M. and BRÁZDA, V. and KAURA, P. and ŠŤASTNÝ, J. and KOLOMAZNÍK, J. and COUFAL, J. and GOSWAMI, P. and ČERVEŇ, J. and PEČINKA, P.",
title="The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria",
journal="MOLECULES",
year="2019",
volume="24",
number="9",
pages="1--13",
doi="10.3390/molecules24091711",
issn="1420-3049",
url="https://www.mdpi.com/journal/molecules/special_issues/Gquadruplex_Microorganisms#published"
}