Detail publikace

Attenuation of p53-alpha isoform transactivation by inverted repeat sequernces in p53 target sites

Originální název

Attenuation of p53-alpha isoform transactivation by inverted repeat sequernces in p53 target sites

Anglický název

Attenuation of p53-alpha isoform transactivation by inverted repeat sequernces in p53 target sites

Jazyk

en

Originální abstrakt

p53 is one of the most studied tumour suppressor proteins, playing important roles in regulation basic biological processes. p53 function is realized by binding to specific DNA response elements resulting in the transactivation of target genes. Here we present results of p53 alpha isoform obtained using a yeast isogenic system for in vivo transactivation studies in chromosomal context to specifically evaluate the influence of secondary DNA structures on transactivation.

Anglický abstrakt

p53 is one of the most studied tumour suppressor proteins, playing important roles in regulation basic biological processes. p53 function is realized by binding to specific DNA response elements resulting in the transactivation of target genes. Here we present results of p53 alpha isoform obtained using a yeast isogenic system for in vivo transactivation studies in chromosomal context to specifically evaluate the influence of secondary DNA structures on transactivation.

BibTex


@misc{BUT157761,
  author="Václav {Brázda} and Otília {Porubiaková} and Natália {Bohálová} and Alberto {Inga} and Miroslav {Fojta}",
  title="Attenuation of p53-alpha isoform transactivation by inverted repeat sequernces in p53 target sites",
  annote="p53 is one of the most studied tumour suppressor proteins, playing important roles in regulation basic biological processes. p53 function is realized by binding to specific DNA response elements resulting in the transactivation of target genes. Here we present results of p53 alpha isoform obtained using a yeast isogenic system for in vivo transactivation studies in chromosomal context to specifically evaluate the influence of secondary DNA structures on transactivation.",
  chapter="157761",
  howpublished="online",
  year="2019",
  month="july",
  pages="1--1",
  type="abstract"
}

Odpovědnost: Ing. Jan Brada