Detail publikačního výsledku
p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system
PORUBIAKOVÁ, O.; BRÁZDA, V.; BOHÁLOVÁ, N.
Originální název
p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system
Anglický název
p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system
Druh
Abstrakt
Originální abstrakt
Protein p53 is one of the most studied tumour suppressor proteins, plays important roles in regulating basic biological processes. The human p53 gene contains alternative promoters and thanks to alternative splicing could be expressed in several isoforms. P53 protein function is realized by DNA-binding and transactivation of target genes. In this paper results of p53alpha isoform DNA interaction studies by yeast isogenic system for in vivo transactivation studies in chromosomal context were presented.
Anglický abstrakt
Protein p53 is one of the most studied tumour suppressor proteins, plays important roles in regulating basic biological processes. The human p53 gene contains alternative promoters and thanks to alternative splicing could be expressed in several isoforms. P53 protein function is realized by DNA-binding and transactivation of target genes. In this paper results of p53alpha isoform DNA interaction studies by yeast isogenic system for in vivo transactivation studies in chromosomal context were presented.
Klíčová slova
p53alpha isoforms, yeast isogenic system, cruciforms
Klíčová slova v angličtině
p53alpha isoforms, yeast isogenic system, cruciforms
Autoři
PORUBIAKOVÁ, O.; BRÁZDA, V.; BOHÁLOVÁ, N.
Vydáno
07.05.2019
BibTex
@misc{BUT157762,
author="Otília {Porubiaková} and Václav {Brázda} and Natália {Bohálová}",
title="p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system",
year="2019",
note="Abstract"
}