Detail publikačního výsledku
Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds
DORAZILOVÁ, J.; MUCHOVÁ, J.; ŠMERKOVÁ, K.; KOČIOVÁ, S.; DIVIŠ, P.; KOPEL, P.; VESELÝ, R.; PAVLIŇÁKOVÁ, V.; ADAM, V.; VOJTOVÁ, L.
Originální název
Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds
Anglický název
Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds
Druh
Článek WoS
Originální abstrakt
A highly porous scaffold is a desirable outcome in the field of tissue engineering. The porous structure mediates water-retaining properties that ensure good nutrient transportation as well as creates a suitable environment for cells. In this study, porous antibacterial collagenous scaffolds containing chitosan and selenium nanoparticles (SeNPs) as antibacterial agents were studied. The addition of antibacterial agents increased the application potential of the material for infected and chronic wounds. The morphology, swelling, biodegradation, and antibacterial activity of collagen-based scaffolds were characterized systematically to investigate the overall impact of the antibacterial additives. The additives visibly influenced the morphology, water retaining properties as well as the stability of the materials in the presence of collagenase enzymes. Even at concentrations as low as 5 ppm of SeNPs, modified polymeric scaffolds showed considerable inhibition activity towards Gram-positive bacterial strains such as Staphylococcus aureus and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis in a dose-dependent manner.
Anglický abstrakt
A highly porous scaffold is a desirable outcome in the field of tissue engineering. The porous structure mediates water-retaining properties that ensure good nutrient transportation as well as creates a suitable environment for cells. In this study, porous antibacterial collagenous scaffolds containing chitosan and selenium nanoparticles (SeNPs) as antibacterial agents were studied. The addition of antibacterial agents increased the application potential of the material for infected and chronic wounds. The morphology, swelling, biodegradation, and antibacterial activity of collagen-based scaffolds were characterized systematically to investigate the overall impact of the antibacterial additives. The additives visibly influenced the morphology, water retaining properties as well as the stability of the materials in the presence of collagenase enzymes. Even at concentrations as low as 5 ppm of SeNPs, modified polymeric scaffolds showed considerable inhibition activity towards Gram-positive bacterial strains such as Staphylococcus aureus and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis in a dose-dependent manner.
Klíčová slova
tissue engineering; drug release; freeze-drying; collagen; chitosan; selenium nanoparticles; infected burn injuries; bacteria; Staphylococcus
Klíčová slova v angličtině
tissue engineering; drug release; freeze-drying; collagen; chitosan; selenium nanoparticles; infected burn injuries; bacteria; Staphylococcus
Autoři
DORAZILOVÁ, J.; MUCHOVÁ, J.; ŠMERKOVÁ, K.; KOČIOVÁ, S.; DIVIŠ, P.; KOPEL, P.; VESELÝ, R.; PAVLIŇÁKOVÁ, V.; ADAM, V.; VOJTOVÁ, L.
Rok RIV
2021
Vydáno
05.10.2020
Nakladatel
MDPI
Místo
Basel
ISSN
2079-4991
Periodikum
Nanomaterials
Svazek
10
Číslo
10
Stát
Švýcarská konfederace
Strany od
1971
Strany do
1992
Strany počet
21
URL
Plný text v Digitální knihovně
BibTex
@article{BUT165864,
author="Jana {Matulová} and Johana {Muchová} and Kristýna {Šmerková} and Silvia {Kočiová} and Pavel {Diviš} and Pavel {Kopel} and Radek {Veselý} and Veronika {Pavliňáková} and Vojtěch {Adam} and Lucy {Vojtová}",
title="Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds",
journal="Nanomaterials",
year="2020",
volume="10",
number="10",
pages="1971--1992",
doi="10.3390/nano10101971",
issn="2079-4991",
url="https://www.mdpi.com/2079-4991/10/10/1971"
}Dokumenty