Detail publikace

Aminoclay as Drug Carrier

DUŠEK, J.

Originální název

Aminoclay as Drug Carrier

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

This study aimed to prepare new drug delivery system with use of aminoclay complexes to enhance the drug release and improve bioavailability of selected drugs. Aminoclay is a relatively new material that belongs to organically modified clays. It is a magnesium phylosilicate that contains 3-aminopropyl groups. The clay material thus modified is characterised by relatively good chemical and mechanical stability, showing no signs of toxicity even at higher concentration. Thanks to easy preparation, and thermal and mechanical stability of inorganic matrix and external amino groups is aminoclay a material with great potential for many applications. By binding the drug to the aminoclay matrix it is expected to improve properties such as solubility, stability, release, bioavailability, biodegradation, etc. For model samples was used a selection of the bioactive substances: curcumin, diclofenac, ibuprofen, merocyanin and tocopherol. For verification of binding drugs were used methods of FTIR (Fourier Transformation Infrared Spectroscopy) and EA (Elemental Analysis). Furthermore, the content of the bound bioactive substances to the aminoclay matrix was investigated using UPLC (Ultra Performance Liquid Chromatography). What is essential for therapeutic use of bioactive substances is their value of cytotoxicity. For this study MTT test for evaluation of cytotoxicity was used. The main motivation of this study was to create new complexes with improved characteristics that would replace existing forms of substances used in pharmaceutical and biomedical applications.

Klíčová slova

aminoclay, carrier, drug

Autoři

DUŠEK, J.

Vydáno

26. 11. 2020

Nakladatel

Vysoké učení technické v Brně, Fakulta chemická

Místo

Brno

ISBN

987-80-214-5920-0

Kniha

Studentská odborná konference CHEMIE JE ŽIVOT 2020

Číslo edice

první

Strany od

57

Strany do

58

Strany počet

2

BibTex

@misc{BUT172705,
  author="Jakub {Dušek}",
  title="Aminoclay as Drug Carrier",
  booktitle="Studentská odborná konference 
CHEMIE JE ŽIVOT 2020",
  year="2020",
  edition="první",
  pages="57--58",
  publisher="Vysoké učení technické v Brně, Fakulta chemická",
  address="Brno",
  isbn="987-80-214-5920-0",
  note="abstract"
}