A Physico-Chemical Point of View on Membrane Properties of Inhalable Colloidal Systems

A Physico-Chemical Point of View on Membrane Properties of Inhalable Colloidal Systems

Abstrakt

This contribution aims to propose a characterisation of colloidal systems, especially vesicular systems, with regard to the use of these systems in the inhalation administration of biologically active substances. Fluorescence spectroscopy, dynamic and electrophoretic light scattering techniques were chosen as characterisation techniques. These methods are very suitable for dilute aqueous solutions of vesicles, which represent the basic colloidal system, which is able to solubilise and carry a wide range of biologically active substances, namely water-insoluble, amphiphilic, and, upon subsequent purification, water-soluble substances. Given the expected use of these systems as carriers of water-insoluble and amphiphilic substances, attention is paid in particular to the physicochemical properties of the vesicular membrane, which, with its properties, influences the process of solubilisation of biologically active substances and the overall stability of formulated vesicular systems. Given this fact, data for different types of vesicular systems from measurements of size, zeta potential, hydration and membrane fluidity are correlated to observe the dynamics between the intrinsic local properties of the membrane with the overall characteristics of the formulated vesicular systems. This correlation will subsequently be used to describe the influence of the type of nebulisation, necessary for inhalation delivery of aqueous solutions, on membrane stability and properties. ACKNOWLEDGEMENTS: This project is supported by Interfaculty Junior Project 'Vesicular system for inhalation delivery of biologically active substances and efficiency of its transport to the deeper parts of the respiratory tract' (FCH/FSI-J-25-8785).

This contribution aims to propose a characterisation of colloidal systems, especially vesicular systems, with regard to the use of these systems in the inhalation administration of biologically active substances. Fluorescence spectroscopy, dynamic and electrophoretic light scattering techniques were chosen as characterisation techniques. These methods are very suitable for dilute aqueous solutions of vesicles, which represent the basic colloidal system, which is able to solubilise and carry a wide range of biologically active substances, namely water-insoluble, amphiphilic, and, upon subsequent purification, water-soluble substances. Given the expected use of these systems as carriers of water-insoluble and amphiphilic substances, attention is paid in particular to the physicochemical properties of the vesicular membrane, which, with its properties, influences the process of solubilisation of biologically active substances and the overall stability of formulated vesicular systems. Given this fact, data for different types of vesicular systems from measurements of size, zeta potential, hydration and membrane fluidity are correlated to observe the dynamics between the intrinsic local properties of the membrane with the overall characteristics of the formulated vesicular systems. This correlation will subsequently be used to describe the influence of the type of nebulisation, necessary for inhalation delivery of aqueous solutions, on membrane stability and properties. ACKNOWLEDGEMENTS: This project is supported by Interfaculty Junior Project 'Vesicular system for inhalation delivery of biologically active substances and efficiency of its transport to the deeper parts of the respiratory tract' (FCH/FSI-J-25-8785).

MÁLKOVÁ, I.; KÁNSKÁ, J.; LÍZAL, F.; MRAVEC, F.

15.10.2025

TANGER Ltd.

978-80-88365-28-0

Sborník abstraktů 17th International Conference on Nanomaterials - Research & Application (NANOCON 2025)

115

116

154

https://nanocon2025.tanger.cz/cz/sbornik-abstraktu/