3D PRINTABLE POLY(ETHYLENE GLYCOL) BASED HYDROGELS AS AUSPICIOUS MATERIAL FOR DRUG DELIVERY SYSTEMS

3D PRINTABLE POLY(ETHYLENE GLYCOL) BASED HYDROGELS AS AUSPICIOUS MATERIAL FOR DRUG DELIVERY SYSTEMS

Abstrakt

Hydrogels are three-dimensional polymer networks with high water content and flexibility. Their properties can be tailored by adjusting polymer concentration, solvent, or additives. Due to their softness, elasticity, biocompatibility, and responsiveness to external stimuli, they are considered smart materials with broad application potential. They are classified as physical or chemical. Physical hydrogels are formed through non-covalent interactions and are generally less stable, often undergoing gel–sol transitions with temperature changes. Chemical hydrogels are created by covalent cross-linking, forming stable three-dimensional networks. Poly(ethylene glycol) (PEG), composed of repeating ethylene glycol units [–(CH₂CH₂O)ₙ–], is widely used for chemically cross-linked hydrogels because of its flexibility, hydrophilicity, and biocompatibility. PEG-based hydrogels are commonly prepared by photopolymerization of PEG diacrylate (PEG-DA) using UV or visible light initiators, enabling rapid and spatially controlled curing. This makes PEG-DA particularly suitable for 3D printing of customizable hydrogel carrier systems.

Hydrogels are three-dimensional polymer networks with high water content and flexibility. Their properties can be tailored by adjusting polymer concentration, solvent, or additives. Due to their softness, elasticity, biocompatibility, and responsiveness to external stimuli, they are considered smart materials with broad application potential. They are classified as physical or chemical. Physical hydrogels are formed through non-covalent interactions and are generally less stable, often undergoing gel–sol transitions with temperature changes. Chemical hydrogels are created by covalent cross-linking, forming stable three-dimensional networks. Poly(ethylene glycol) (PEG), composed of repeating ethylene glycol units [–(CH₂CH₂O)ₙ–], is widely used for chemically cross-linked hydrogels because of its flexibility, hydrophilicity, and biocompatibility. PEG-based hydrogels are commonly prepared by photopolymerization of PEG diacrylate (PEG-DA) using UV or visible light initiators, enabling rapid and spatially controlled curing. This makes PEG-DA particularly suitable for 3D printing of customizable hydrogel carrier systems.

poly(ethylene glycol), 3D printing, drug release, diffusion, tuneable properties

poly(ethylene glycol), 3D printing, drug release, diffusion, tuneable properties

SOKOLÍNSKÝ, J.; KREUZEROVÁ, M.; MICHLOVSKÁ, L.; SEDLÁČEK, P.

11.12.2025

Vysoké učení technické v Brně

Brno

978-80-214-6388-2

sborník abstraktů-Chemistry is life 2025

91

https://www.fch.vut.cz/vav/konference/sok/vystupy