Detail publikačního výsledku

N,N,N-Trimethyl chitosan as a permeation enhancer for inhalation drug delivery: Interaction with a model pulmonary surfactant

SZABOVÁ, J.; MRAVEC, F.; MOKHTARI, M.; LE BORGNE, R.; KALINA, M.; BERRET, J.

Originální název

N,N,N-Trimethyl chitosan as a permeation enhancer for inhalation drug delivery: Interaction with a model pulmonary surfactant

Anglický název

N,N,N-Trimethyl chitosan as a permeation enhancer for inhalation drug delivery: Interaction with a model pulmonary surfactant

Druh

Článek WoS

Originální abstrakt

N,N,N-Trimethyl chitosan (TMC), a biocompatible and biodegradable derivative of chitosan, is currently used as a permeation enhancer to increase the translocation of drugs to the bloodstream in the lungs. This article discusses the effect of TMC on a mimetic pulmonary surfactant, Curosurf®, a low-viscosity lipid formulation administered to preterm infants with acute respiratory distress syndrome. Curosurf® exhibits a strong interaction with TMC, resulting in the formation of aggregates at electrostatic charge stoichiometry. At nanoscale, Curosurf® undergoes a profound reorganization of its lipid vesicles in terms of size and lamellarity. The initial micron-sized vesicles (average size 4.8 μm) give way to a froth-like network of unilamellar vesicles about 300 nm in size. Under such conditions, neutralization of the cationic charges by pulmonary surfactant may inhibit TMC permeation enhancer capacity, especially as electrostatic charge complexation is found at low TMC content. The permeation properties of pulmonary surfactant-neutralized TMC should then be evaluated for its applicability as a permeation enhancer for inhalation in the alveolar region.

Anglický abstrakt

N,N,N-Trimethyl chitosan (TMC), a biocompatible and biodegradable derivative of chitosan, is currently used as a permeation enhancer to increase the translocation of drugs to the bloodstream in the lungs. This article discusses the effect of TMC on a mimetic pulmonary surfactant, Curosurf®, a low-viscosity lipid formulation administered to preterm infants with acute respiratory distress syndrome. Curosurf® exhibits a strong interaction with TMC, resulting in the formation of aggregates at electrostatic charge stoichiometry. At nanoscale, Curosurf® undergoes a profound reorganization of its lipid vesicles in terms of size and lamellarity. The initial micron-sized vesicles (average size 4.8 μm) give way to a froth-like network of unilamellar vesicles about 300 nm in size. Under such conditions, neutralization of the cationic charges by pulmonary surfactant may inhibit TMC permeation enhancer capacity, especially as electrostatic charge complexation is found at low TMC content. The permeation properties of pulmonary surfactant-neutralized TMC should then be evaluated for its applicability as a permeation enhancer for inhalation in the alveolar region.

Klíčová slova

N,N,N-Trimethyl chitosan, Pulmonary surfactant, Electrostatic complexation, Polyelectrolytes, Lipid vesicles,Permeation enhancer

Klíčová slova v angličtině

N,N,N-Trimethyl chitosan, Pulmonary surfactant, Electrostatic complexation, Polyelectrolytes, Lipid vesicles,Permeation enhancer

Autoři

SZABOVÁ, J.; MRAVEC, F.; MOKHTARI, M.; LE BORGNE, R.; KALINA, M.; BERRET, J.

Rok RIV

2024

Vydáno

01.06.2023

Nakladatel

Elsevier Science BV

Místo

Holandsko

ISSN

0141-8130

Periodikum

International Journal of Biological Macromolecules

Svazek

239

Číslo

June

Stát

Nizozemsko

Strany od

1

Strany do

11

Strany počet

11

URL

https://www.sciencedirect.com/science/article/pii/S0141813023011297

Plný text v Digitální knihovně

http://hdl.handle.net/

BibTex

@article{BUT183228,
  author="Jana {Szabová} and Filip {Mravec} and Mostafa {Mokhtari} and Rémi {Le Borgne} and Michal {Kalina} and Jean-François {Berret}",
  title="N,N,N-Trimethyl chitosan as a permeation enhancer for inhalation drug delivery: Interaction with a model pulmonary surfactant",
  journal="International Journal of Biological Macromolecules",
  year="2023",
  volume="239",
  number="June",
  pages="1--11",
  doi="10.1016/j.ijbiomac.2023.124235",
  issn="0141-8130",
  url="https://www.sciencedirect.com/science/article/pii/S0141813023011297"
}