Detail publikace

Complex Biophysical and Computational Analyses of G‐Quadruplex Ligands: The Porphyrin Stacks Back

SATTA, G. TRAJKOVSKI, M. CANTARA, A. MURA, M. MELONI, C. OLLA, G. DOBROVOLNÁ, M. PISANO, L. GASPA, S. SALIS, A. DE LUCA, L. MOCCI, F. BRÁZDA, V. PLAVEC, J. CARRARO, M.

Originální název

Complex Biophysical and Computational Analyses of G‐Quadruplex Ligands: The Porphyrin Stacks Back

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

G-quadruplexes (G4 s), as non-canonical DNA structures, attracta great deal of research interest in the molecular biology as wellas in the material science fields. The use of small molecules asligands for G-quadruplexes has emerged as a tool to regulategene expression and telomeres maintenance. Meso-tetrakis-(N-methyl-4-pyridyl) porphyrin (TMPyP4) was shown as one of thefirst ligands for G-quadruplexes and it is still widely used. Wereport an investigation comprising molecular docking anddynamics, synthesis and multiple spectroscopic and spectro-metric determinations on simple cationic porphyrins and theirinteraction with different DNA sequences. This study enabledthe synthesis of tetracationic porphyrin derivatives that ex-hibited binding and stabilizing capacity against G-quadruplexstructures; the detailed characterization has shown that thepresence of amide groups at the periphery improves selectivityfor parallel G4 s binding over other structures. Taking intoaccount the ease of synthesis, 5,10,15,20-tetrakis-(1-acetamido-4-pyridyl) porphyrin bromide could be considered a betteralternative to TMPyP4 in studies involving G4 binding.

Klíčová slova

DNA, G-quadruplexes, Molecular dynamics, Molecular recognition, NMR

Autoři

SATTA, G.; TRAJKOVSKI, M.; CANTARA, A.; MURA, M.; MELONI, C.; OLLA, G.; DOBROVOLNÁ, M.; PISANO, L.; GASPA, S.; SALIS, A.; DE LUCA, L.; MOCCI, F.; BRÁZDA, V.; PLAVEC, J.; CARRARO, M.

Vydáno

18. 9. 2024

Nakladatel

Wiley-VCH

ISSN

0947-6539

Periodikum

CHEMISTRY-A EUROPEAN JOURNAL

Ročník

30

Číslo

69

Stát

Spolková republika Německo

Strany od

1

Strany do

13

Strany počet

13

URL

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202402600

Plný text v Digitální knihovně

http://hdl.handle.net/11012/250725

BibTex

@article{BUT190100,
  author="Giuseppe {Satta} and Marko {Trajkovski} and Alessio {Cantara} and Monica {Mura} and Claudia {Meloni} and Giulia {Olla} and Michaela {Dobrovolná} and Luisa {Pisano} and Silvia {Gaspa} and Andrea {Salis} and Lidia {De Luca} and Francesca {Mocci} and Václav {Brázda} and Janez {Plavec} and Massimo {Carraro}",
  title="Complex Biophysical and Computational Analyses of G‐Quadruplex Ligands: The Porphyrin Stacks Back",
  journal="CHEMISTRY-A EUROPEAN JOURNAL",
  year="2024",
  volume="30",
  number="69",
  pages="13",
  doi="10.1002/chem.202402600",
  issn="0947-6539",
  url="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202402600"
}