Detail předmětu

Biophysical Chemistry

FCH-DA_BFCHAk. rok: 2020/2021

The course deals with the application of physical chemistry to biological and biochemical processes and problems. It contains the following parts, which the student chooses according to the topic of the dissertation.
Biothermodynamics: energetics of biological processes, Gibbs energy and its significance for the description of biochemical processes, connections with enthalpy and entropy, application to the fate of ATP in the organism, basics of nonequilibrium thermodynamics. Kinetics of biological processes: enzyme reactions, denaturation and renaturation of proteins, pharmacokinetics. Non-covalent interactions in biological systems: types of interactions, spatial arrangement of biopolymers, their stability and denaturation, interactions with ligands. Biological membranes: amphiphilic biomolecules, structure and properties of membranes, transport across membranes. Water and hydration: structure and properties of water, water as a biological environment, hydration of biopolymers. Biological polyelectrolytes: dissociation, acid-base properties, effect of pH.

Prerekvizity

There are no prerequisites

Doporučená nebo povinná literatura

Atkins, P.; de Paula, J. Physical Chemistry for the Life Sciences. Oxford: Oxford University Press, 2006 (EN)
Haynie, D.T. Biological Thermodynamics. Cambridge: Cambridge University Press, 2008. (EN)

Způsob a kritéria hodnocení

Study results are verified by a colloquium (Study and Examination Rules of BUT, Art. 34), which means a discussion on the subject matter, connected with the elaboration of a written work dealing with the assigned subject matter in the range of about 20 text pages; the debate lasts about 30 minutes.

Jazyk výuky

angličtina

Osnovy výuky

The course deals with the application of physical chemistry to biological and biochemical processes and problems. It contains the following parts, which the student chooses according to the topic of the dissertation.
Biothermodynamics: energetics of biological processes, Gibbs energy and its significance for the description of biochemical processes, connections with enthalpy and entropy, application to the fate of ATP in the organism, basics of nonequilibrium thermodynamics. Kinetics of biological processes: enzyme reactions, denaturation and renaturation of proteins, pharmacokinetics. Non-covalent interactions in biological systems: types of interactions, spatial arrangement of biopolymers, their stability and denaturation, interactions with ligands. Biological membranes: amphiphilic biomolecules, structure and properties of membranes, transport across membranes. Water and hydration: structure and properties of water, water as a biological environment, hydration of biopolymers. Biological polyelectrolytes: dissociation, acid-base properties, effect of pH.

Zařazení předmětu ve studijních plánech

  • Program DKCP_BCH bakalářský

    specializace () , 1. ročník, zimní semestr, 0 kreditů, povinný

  • Program DPAP_BCH doktorský, 1. ročník, zimní semestr, 0 kreditů, povinný
  • Program DKAP_BCH doktorský, 1. ročník, zimní semestr, 0 kreditů, povinný

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