Detail publikace

„Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release

LYSÁKOVÁ, K. HLINÁKOVÁ, K. BRTNÍKOVÁ, J. VOJTOVÁ, L.

Originální název

„Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

There is a strong emphasis on controlled drug delivery systems at this time. In this work stable Fibroblast growth factor 2 (FGF2-stab), developed by the Enantis company (Brno, CZ), was used as a protein-based drug. FGF2-stab stimulates the growth and the development of new vessels (angiogenesis), leading to improved wound healing, tissue development and contributes to the pathogenesis of several diseases (cancer or atherosclerosis). Amphiphilic PLGA-PEG-PLGA triblock copolymer was used as the biodegradable water-soluble copolymer that undergoes to a gel at physiological temperature. Along with increasing temperature in an aqueous environment, the PLGA-PEG-PLGA copolymer forms micelles having the hydrophobic core (PLGA) and the hydrophilic shell surface (PEG). Nowadays, drug carriers based on PLGA-PEG-PLGA copolymers are already commercially available under the names ReGel® and OncoGel® loaded with insulin or paclitaxel, respectively.

Klíčová slova

regenerative medicine, tissue engineering, biodegradable hydrogel matrix, protein release

Autoři

LYSÁKOVÁ, K.; HLINÁKOVÁ, K.; BRTNÍKOVÁ, J.; VOJTOVÁ, L.

Vydáno

14. 6. 2021

Nakladatel

eCM Meeting Abstracts

ISSN

2522-235X

Periodikum

eCM Periodical

Ročník

2021

Číslo

1

Stát

Švýcarská konfederace

Strany od

25

Strany do

25

Strany počet

1

URL

https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html

BibTex

@misc{BUT175063,
  author="Klára {Lysáková} and Kristýna {Hlináková} and Jana {Brtníková} and Lucy {Vojtová}",
  title="„Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release",
  year="2021",
  journal="eCM Periodical",
  volume="2021",
  number="1",
  pages="25--25",
  publisher="eCM Meeting Abstracts",
  issn="2522-235X",
  url="https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html",
  note="abstract"
}